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. 2020 Jul;20(7):392-394.
doi: 10.1038/s41577-020-0359-5. Epub 2020 Jun 8.

Dissecting antibody-mediated protection against SARS-CoV-2

Tomer Zohar  1   2 , Galit Alter  3
Affiliations

Dissecting antibody-mediated protection against SARS-CoV-2

Tomer Zohar et al. Nat Rev Immunol. 2020 Jul.

Abstract

Understanding the properties and mechanisms by which antibodies provide protection is essential to defining immunity. Although neutralizing antibodies have been proposed as a potential key mechanism of protection against many viral pathogens, antibodies mediate additional immune functions that may have both protective and pathological consequences. Dissecting these properties against SARS-CoV-2 is likely necessary for defining metrics of immunity that will inform the design of vaccines and therapeutics and improve clinical management.

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Conflict of interest statement

G.A. is a founder of Seromyx Inc. T.Z. declares no competing interests.

Figures

Fig. 1
Fig. 1. Antibody functions and their contributions to inflammation.
Polyclonal pools are comprised of antibodies with unique Fc structure and antigen specificity. Collectively, profiles result in different functions and downstream consequences. FcR, Fc receptor; NK, natural killer; Treg cell, regulatory T cell.
See this image and copyright information in PMC

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