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. 2019 Nov 14;4(3):461-465.
doi: 10.1002/jgh3.12279. eCollection 2020 Jun.

Outcome of acute pancreatitis in octogenarians: A retrospective study

Davide Di Mauro  1 , Chinthaka N Wijesurendere  1 , Andrea Attanasio  1 , Claudia A M Fulgenzi  1 , Iyad Elkhuffash  2 , Edoardo Ricciardi  1 , Shahjehan Wajed  1 , Antonio Manzelli  1
Affiliations

Outcome of acute pancreatitis in octogenarians: A retrospective study

Davide Di Mauro et al. JGH Open. .

Abstract

Background and aim: Acute pancreatitis (AP) is a common disease, but data on outcomes in octogenarians are scarce in the literature. The aim of this study is to analyze results from patients aged 80 years old and over who were treated for AP at a single center.

Methods: Patients aged 80 years and older diagnosed with AP from April 2010 to October 2015 were considered. Demographics, American Society of Anesthesiologists (ASA) score, Charlson Comorbidity Index (CCI), serum biochemistry at 24 and 48 h after admission, and revised Atlanta severity score were analyzed and correlated with hospital mortality rate and length of stay using the multiple regression and Kaplan-Meier tests.

Results: A total of 100 consecutive patients were included in the study. There were 52 women, and the mean age was 87.5 years (range 80-95). Gallstones were the most common cause of AP (69.7%). The ASA score was ≥III in 51 patients. Eight patients had severe, disease and all of them died in hospital. A CCI > 4 was associated with higher disease severity and mortality (P < 0.00001). The median hospital stay was 9 days (range 1-59). Longer hospital stay was associated with serum C-reactive protein ≥242 mg/L (P = 0.01) and serum albumin ≤30 g/L (P = 0.01) at 48 h. Over a 5-year period, 22% of patients were readmitted to hospital with recurrent AP. Gallstones were the main cause of disease (63.6%).

Conclusions: AP in octogenarians has low mortality. Higher death rate is associated with disease severity. In the presence of gallstone disease, cholecystectomy is recommended whenever possible as the risk of disease recurrence is significant.

Keywords: acute pancreatitis; clinical outcome; octogenarians.

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Figures

Figure 1
Figure 1
Inclusion and exclusion criteria.
Figure 2
Figure 2
Causes of acute pancreatitis. ERCP, endoscopic retrograde cholangiopancreatography.
Figure 3
Figure 3
Charlson Comorbidity Index and mortality. (formula image), 4; (formula image), >4; (formula image), 4‐censored; (formula image) >4‐censored. CCI, Charlson Comorbidity Index.
See this image and copyright information in PMC

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