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. 2020 Nov 1;75(11):3087-3095.
doi: 10.1093/jac/dkaa205.

Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9

Zhuoren Ling  1   2 , Wenjuan Yin  3 , Zhangqi Shen  1 , Yang Wang  1 , Jianzhong Shen  1 , Timothy R Walsh  1   2
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Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9

Zhuoren Ling et al. J Antimicrob Chemother. .

Abstract

The identification of the first mobile colistin resistance (MCR) gene, mcr-1, in 2015 triggered a rash of mcr screening reports. Subsequently, nine MCR-family genes and their variants have been described. However, a comprehensive overview concerning the epidemiology of the whole MCR family, which is essential for facilitating rational interventions against mcr dissemination, is lacking. Here, based on the National Database of Antibiotic Resistant Organisms and published studies, we have summarized the latest epidemiological characteristics of the mcr genes.

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