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Review
. 2020 Nov;23(6):951-960.
doi: 10.1007/s10120-020-01095-z. Epub 2020 Jun 8.

Epstein-Barr virus-associated gastric cancer: disease that requires special approach

Ekaterina Ignatova  1 , Daria Seriak  2 , Mikhail Fedyanin  3 , Alexey Tryakin  3 , Ilya Pokataev  3 , Sofia Menshikova  4 , Yuliya Vakhabova  5 , Ksenia Smirnova  6 , Sergey Tjulandin  3 , Jaffer A Ajani  7
Affiliations
Review

Epstein-Barr virus-associated gastric cancer: disease that requires special approach

Ekaterina Ignatova et al. Gastric Cancer. 2020 Nov.

Abstract

Epstein-Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA, ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.

Keywords: Epstein–Barr virus; Epstein–Barr virus infection; Gastric cancer; Oesophago-gastric cancer; Stomach cancer.

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