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Review
. 2020 Sep;72(9):1856-1869.
doi: 10.1002/iub.2325. Epub 2020 Jun 9.

Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism

Rasoul Mirzaei  1 , Rokhsareh Mohammadzadeh  2 , Hamed Mirzaei  3 , Mohammad Sholeh  2 , Sajad Karampoor  4 , Milad Abdi  2   5 , Mohammad Yousef Alikhani  1 , Sima Kazemi  1 , Yaghoub Ahmadyousefi  6   7 , Saba Jalalifar  2 , Rasoul Yousefimashouf  1
Affiliations
Free article
Review

Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism

Rasoul Mirzaei et al. IUBMB Life. 2020 Sep.
Free article

Abstract

Staphylococcus aureus is known as a common pathogen that colonizes 30% of healthy humans. Additionally, this bacterium can cause a number of serious infections, that is, endocarditis, bacteremia, pneumonia, wound, skin infections, and tissue abscesses. A variety of cellular and molecular pathways and targets are involved in response against S. aureus. Among them, microRNAs (miRNAs) have crucial roles in response against S. aureus. In this regard, it has been shown that these molecules exert their regulatory roles via modulating a wide range of events, such as inflammatory reactions, host innate, and adaptive immunity. Current works have provided insight into the crucial involvement of miRNAs in immune defense toward Staphylococcal infections. Herein, we highlighted the current findings on the deregulation of different miRNAs in S. aureus-infected cells. Moreover, we summarized the mechanisms and targets of miRNAs in S. aureus infections.

Keywords: Staphylococcus aureus; immune response: Biomarker; infection; microRNAs.

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References

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