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Comment
. 2020 Jun 8;37(6):761-763.
doi: 10.1016/j.ccell.2020.05.015.

CAR T Cells for Mantle Cell Lymphoma: Is it Time to Reshuffle the Deck?

Craig S Sauter  1 , Renier J Brentjens  2
Affiliations
Free article
Comment

CAR T Cells for Mantle Cell Lymphoma: Is it Time to Reshuffle the Deck?

Craig S Sauter et al. Cancer Cell. .
Free article

Abstract

In the New England Journal of Medicine, Wang et al. report favorable ZUMA-2 trial results of CAR T cells for patients with relapsed and refractory mantle cell lymphoma following prior failed Bruton's tyrosine kinase inhibitor therapy, with an overall response rate of 93% and an expected safety profile.

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Conflict of interest statement

Declaration of Interests C.S.S. has served as a paid consultant on advisory boards for Juno Therapeutics, Sanofi-Genzyme, Spectrum Pharmaceuticals, Novartis, Genmab, Precision Biosciences, Kite/a Gilead Company, Celgene, Gamida Cell, and GSK and has received research funds for clinical trials from Juno Therapeutics, Celgene, Precision Biosciences, and Sanofi-Genzyme. R.J.B. has patents and receives royalties and grant support from Juno Therapeutics and is a consultant and advisor for Gracell Therapeutics, Inc.

Comment on

  • KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma.
    Wang M, Munoz J, Goy A, Locke FL, Jacobson CA, Hill BT, Timmerman JM, Holmes H, Jaglowski S, Flinn IW, McSweeney PA, Miklos DB, Pagel JM, Kersten MJ, Milpied N, Fung H, Topp MS, Houot R, Beitinjaneh A, Peng W, Zheng L, Rossi JM, Jain RK, Rao AV, Reagan PM. Wang M, et al. N Engl J Med. 2020 Apr 2;382(14):1331-1342. doi: 10.1056/NEJMoa1914347. N Engl J Med. 2020. PMID: 32242358 Free PMC article. Clinical Trial.

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