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Comment
. 2020 Jun 8;53(5):500-502.
doi: 10.1016/j.devcel.2020.05.004.

Understanding Complexity of Cancer Genomes: Lessons from Errors

Sara Martin  1 , Stefano Santaguida  2
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Understanding Complexity of Cancer Genomes: Lessons from Errors

Sara Martin et al. Dev Cell. .
Free article

Abstract

Deconstructing the events leading to cancer genome rearrangements is key to understanding tumorigenesis. In a recent issue of Science, Umbreit, Zhang et al. elegantly show that complex genome evolution is the result of a cascade of events initiated by a single error during cell division.

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  • Chromothripsis from DNA damage in micronuclei.
    Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D. Zhang CZ, et al. Nature. 2015 Jun 11;522(7555):179-84. doi: 10.1038/nature14493. Epub 2015 May 27. Nature. 2015. PMID: 26017310 Free PMC article.

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