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Comment
. 2020 Jun 9;13(635):eabb8834.
doi: 10.1126/scisignal.abb8834.

The interdependence of renal epithelial and endothelial metabolism and cell state

Michael S Balzer  1   2 , Katalin Susztak  1   2
Affiliations
Comment

The interdependence of renal epithelial and endothelial metabolism and cell state

Michael S Balzer et al. Sci Signal. .

Abstract

In this issue of Science Signaling, Lovisa et al. demonstrate the contribution of endothelial-to-mesenchymal transition (EndMT) to kidney fibrosis development. Their studies reveal the interdependence of endothelial and epithelial metabolism in health and disease.

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Conflict of interest statement

Competing interests: K.S. received consulting fees from Maze Biotech, Jnana Therapeutics, Duke-NUS, Janssen, and Chemocentryx. In addition, the laboratory of K.S. is supported by Gilead, Boehringer Ingelheim, GSK, Regeneron, Merck, and Bayer.

Figures

Fig. 1.
Fig. 1.. EndMT links renal epithelial and endothelial metabolism.
Kidney tubule cell metabolic reprogramming toward decreased fatty acid oxidation (FAO) and increased glycolysis as hallmarks of kidney disease progression depend on EndMT, which triggers vascular leakage and tissue hypoxia.
See this image and copyright information in PMC

Comment on

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