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Review
. 2020 Nov;92(11):2458-2464.
doi: 10.1002/jmv.26157. Epub 2020 Jun 29.

Extrapulmonary and atypical clinical presentations of COVID-19

Affiliations
Review

Extrapulmonary and atypical clinical presentations of COVID-19

Anis Abobaker et al. J Med Virol. 2020 Nov.

Abstract

The novel coronavirus (SARS-CoV2) has led to an outbreak of multiple cases of pneumonia in Wuhan city in December 2019. The disease caused by this virus was named coronavirus disease 2019 or "COVID-19", which was declared by the World Health Organization as a global pandemic in March 2020. It typically presents with respiratory symptoms and febrile illness. However, there are few reported extrapulmonary and atypical presentations, such as hemoptysis, cardiac, neurological, gastrointestinal, ocular, and cutaneous manifestations, as well as venous and arterial thrombosis. Lack of awareness of these presentations might lead to misdiagnosis, delayed diagnosis, and isolation of suspected patients which increases the risk of transmission of infection between patients and doctors. All these issues will be discussed in this review.

Keywords: COVID-19; SARS-CoV-2; atypical presentations.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

References

    1. WHO |Pneumonia of unknown cause–China [Internet]. WHO. World Health Organization; 2020. http://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-chi.... Accessed April 23, 2020.
    1. Coronavirus Disease (COVID‐19)‐events as they happen [Internet]; 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-a.... Accessed April 4, 2020.
    1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497‐506. - PMC - PubMed
    1. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061‐1069. - PMC - PubMed
    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID‐19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239‐1242. - PubMed