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Editorial
. 2020 Jul 15;202(2):161-163.
doi: 10.1164/rccm.202006-2151ED.

ACE2: The Only Thing That Matters?

Raul Y Sanchez-David  1 , Olivia C Swann  1 , Thomas P Peacock  1 , Wendy S Barclay  1
Affiliations
Editorial

ACE2: The Only Thing That Matters?

Raul Y Sanchez-David et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
In some cells, ACE2 expression is higher (left cell), whereas in other cells, ACE2 expression is lower (right cell). In the case of the airways, this renders the more highly expressing upper airway cells inherently more permissive to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nevertheless, in other cells (central cell), ACE2 expression is high, and yet the population remains resistant to SARS-CoV-2 infection. This phenotype is potentially dictated by the expression levels of additional proviral factors, or restrictive host factors such as IFN-stimulated genes (ISGs).
See this image and copyright information in PMC

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References

    1. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. - PMC - PubMed
    1. Liu W, Tao ZW, Wang L, Yuan ML, Liu K, Zhou L, et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J (Engl) 2020;133:1032–1038. - PMC - PubMed
    1. Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, et al. Angiotensin-converting enzyme 2 metabolizes and partially inactivates Pyr-Apelin-13 and Apelin-17: physiological effects in the cardiovascular system. Hypertension. 2016;68:365–377. - PubMed
    1. Zhang H, Rostami MR, Leopold PL, Mezey JG, O’Beirne SL, Strulovici-Barel Y, et al. Expression of the SARS-CoV-2 ACE2 receptor in the human airway epithelium. Am J Respir Crit Care Med. 2020;202:219–229. - PMC - PubMed
    1. Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. HCA Lung Biological Network. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26:681–687. - PMC - PubMed

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