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. 2020 Sep;30(5):704-718.
doi: 10.1111/jon.12743. Epub 2020 Jun 10.

Microcystic Meningiomas: MRI-Pathologic Correlation

Karthik Kulanthaivelu  1 , Vivek Lanka  1 , Chitra Chandran  1 , Bevinhalli N Nandeesh  2 , Sarbesh Tiwari  3 , Anita Mahadevan  2 , Chandrajit Prasad  1 , Jitender Saini  1 , Maya D Bhat  1 , Dhritiman Chakrabarti  4 , Nupur Pruthi  5 , Vikas Vazhayil  5 , Nishanth Sadashiva  5 , Dwarakanath Srinivas  5
Affiliations

Microcystic Meningiomas: MRI-Pathologic Correlation

Karthik Kulanthaivelu et al. J Neuroimaging. 2020 Sep.

Abstract

Background and purpose: Microcystic meningiomas (MM) are a distinctive, rare subtype of Grade I meningiomas with limited radiological descriptions. We intend to identify unique imaging phenotypes and seek radiopathological correlations.

Methods: Retrospective analysis of histopathologically proven MM was undertaken. Clinicodemographic profiles, imaging, and histopathological characteristics were recorded. Spearman rank correlations among radiological and pathological attributes were performed.

Results: Twenty-eight cases were analyzed (mean age = 45.5 years; M:F = 1:1.54; mean volume = 50.1 mL; supratentorial n = 27). Most lesions were markedly T2 hyperintense (higher than peritumoral brain edema-a unique finding) (89.3%) and showed invariable diffusion restriction, severe peritumoral brain edema (edema index >2 in 64.3%), a "storiform" pattern on T2-weighted images (T2WI) (75%), reticular pattern on postcontrast T1 (78.6%)/diffusion-weighted images (DWI) (65.4%), hyperperfusion, T1 hypointensity (84.6%), and absence of blooming on susceptibility-weighted image (80.9%). Storiform/reticular morphology correlated with large cysts on histopathology (ρ = .56; P = .005753). Lesion dimension positively correlated with reticular morphology on imaging (ρ = .59; P = .001173), higher flow voids (ρ = .65; P = .00027), and greater microcystic changes on histopathology (ρ = .51; P = .006778). Peritumoral brain edema was higher for lesions demonstrating greater angiomatous component (ρ = .46; P = .014451).

Conclusions: We have elucidated varied neuroimaging features and highlighted pathological substrates of crucial imaging findings of MM. MM ought to be considered as an imaging possibility in an extra-axial lesion with a marked hypodensity on noncontrast computed tomography, markedly T2-hyperintense/T1-hypointense signal, and a storiform/reticular pattern on T2W/GdT1w//DWI.

Keywords: Diffusion restriction; meningiomas; microcystic; radiopathological correlation.

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