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Review
. 2020 Aug:226:69-74.
doi: 10.1016/j.ahj.2020.04.027. Epub 2020 May 6.

Cardiovascular implications of idiopathic pulmonary fibrosis: A way forward together?

Christopher L Mosher  1 , Robert J Mentz  2
Affiliations
Review

Cardiovascular implications of idiopathic pulmonary fibrosis: A way forward together?

Christopher L Mosher et al. Am Heart J. 2020 Aug.

Abstract

Cardiovascular disease has an increased prevalence among patients with idiopathic pulmonary fibrosis (IPF). Cardiovascular disease and IPF share similar symptoms with overlapping demographics and risk factors for disease development. Common cellular mediators leading to disease development and progression have been identified in both the cardiovascular and pulmonary organ systems. In this context, discovery of new therapeutic targets and medical therapies could be mutually beneficial across cardiopulmonary diseases. Here we present (1) a clinical review of IPF for the cardiovascular clinician and (2) common cellular mechanisms responsible for fibrosis in the heart and lungs and (3) highlight future research considerations and the potential role of novel therapeutic agents which may be mutually beneficial in cardiac and pulmonary fibrosis.

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Figures

Figure 1
Figure 1
Diagnosis of IPF: diagnostic algorithm for a suspected diagnosis of IPF.
See this image and copyright information in PMC

References

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