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Comparative Study
. 2020 Sep;75(9):805-807.
doi: 10.1136/thoraxjnl-2020-214863. Epub 2020 Jun 10.

Reliability of methods to estimate the fraction of inspired oxygen in patients with acute respiratory failure breathing through non-rebreather reservoir bag oxygen mask

Rémi Coudroy  1   2 , Jean-Pierre Frat  3   2 , Christophe Girault  4   5 , Arnaud W Thille  3   2
Affiliations
Comparative Study

Reliability of methods to estimate the fraction of inspired oxygen in patients with acute respiratory failure breathing through non-rebreather reservoir bag oxygen mask

Rémi Coudroy et al. Thorax. 2020 Sep.

Abstract

Severity of hypoxaemia can be assessed using the partial pressure of arterial oxygen to fraction of inspired oxygen ratio (FiO2). However, in patients breathing through non-rebreather reservoir bag oxygen mask, accuracy of bedside FiO2 estimation methods remains to be tested. In a post-hoc analysis of a multicentre clinical trial, three FiO2 estimation methods were compared with FiO2 measured with a portable oxygen analyser introduced in the oxygen mask. Among 262 patients analysed, mean (SD) measured FiO2 was 65% (13). The 3%-formula (21% + oxygen flow rate in L/min × 3) was the most accurate method to estimate FiO2 Other methods overestimated FiO2 and hypoxaemia severity, so they should be avoided.

Keywords: critical care.

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Conflict of interest statement

Competing interests: RC reported receiving grants from the French Ministry of Health, Le Nouveau Souffle, AADAIRC, French Intensive Care Society and European Respiratory Society, and non-financial support from Fisher & Paykel Healthcare and MSD outside the submitted work. J-PF reported receiving grants from the French Ministry of Health and personal fees and non-financial support from Fisher & Paykel Healthcare outside the submitted work. CG reported non-financial support, personal fees and logistic support from Fisher & Paykel, Resmed and Lowenstein Medical. AWT reported receiving grants from the French Ministry of Health, personal fees and non-financial support from Fisher & Paykel Healthcare, and personal fees from Maquet-Getinge, GE Healthcare and Covidien outside the submitted work.

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