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. 2017;14(2):91-101.
doi: 10.21767/2049-5471.100098. Epub 2017 Apr 10.

Systemic F2-Isoprostane Levels in Predisposition to Obesity and Type 2 Diabetes: Emphasis on Racial Differences

Dora Il'yasova  1 , Brett J Wong  2 , Anna Waterstone  3 , Alexander Kinev  4 , Ike S Okosun  1
Affiliations

Systemic F2-Isoprostane Levels in Predisposition to Obesity and Type 2 Diabetes: Emphasis on Racial Differences

Dora Il'yasova et al. Divers Equal Health Care. 2017.

Abstract

This review focuses on racial differences in systemic levels of lipid peroxidation markers F2-isoprostanes as metabolic characteristics predisposing to obesity and type 2 diabetes. Elevated levels F2-isoprostanes were found in obesity, type 2 diabetes and their comorbidities. It was hypothesized that increased F2-isoprostane levels reflect the obesity-induced oxidative stress that promotes the development of type 2 diabetes. However, African Americans have lower levels of systemic F2-isoprostane levels despite their predisposition to obesity and type 2 diabetes. The review summarizes new findings from epidemiological studies and a novel interpretation of metabolic determinants of systemic F2-isoprostane levels as a favorable phenotype. Multiple observations indicate that systemic F2-isoprostane levels reflect intensity of oxidative metabolism, a major endogenous source of reactive oxygen species, and specifically, the intensity of fat utilization. Evidence from multiple human studies proposes that targeting fat metabolism can be a productive race-specific strategy to address the existing racial health disparities. Urinary F2-isoprostanes may provide the basis for targeted interventions to prevent obesity and type 2 diabetes among populations of African descent.

Keywords: Lipid peroxidation markers; Obesity; Obesity-induced oxidative stress; Public health; Racial disparities; Type 2 diabetes.

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Figures

Figure 1:
Figure 1:
Proposed relationships between urinary F2-isoprostanes and fatty acid oxidation rates.
Figure 2:
Figure 2:
Physiological determinants of elevated metabolic risk associated with low F2-isoprostane levels. (A) Hypothesized relationship between systemic F2-isoprostane levels and skeletal muscle mitochondrial fatty acid oxidation; (B) Hypothesized relationship between skeletal muscle mitochondrial metabolism, systemic F2-isoprostane levels and metabolic predisposition to obesity and type 2 diabetes in African Americans.
See this image and copyright information in PMC

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