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. 2020 Sep;51(3):1088-1093.
doi: 10.1007/s12029-020-00441-9.

Physical Inactivity and Pancreatic Cancer Mortality

Megha Pratapwar  1 , Ashley E Stenzel  2 , Janine M Joseph  2 , Christos Fountzilas  3 , John Lewis Etter  2 , Jennifer M Mongiovi  2 , Rikki Cannioto  2 , Kirsten B Moysich  4
Affiliations

Physical Inactivity and Pancreatic Cancer Mortality

Megha Pratapwar et al. J Gastrointest Cancer. 2020 Sep.

Abstract

Objective: To determine the association between pre-diagnostic recreational physical inactivity (RPI) and pancreatic cancer (PC) mortality.

Methods: This analysis included 107 patients seen at Roswell Park Comprehensive Cancer Center diagnosed with PC between 1989 and 1998. Cox proportional hazards models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for PC mortality associated with self-reported pre-diagnostic RPI. Models were adjusted for known prognostic factors, including age, sex, stage at diagnosis, smoking status, and body mass index (BMI). Results were also stratified by sex, BMI, smoking status, histology, and treatment status.

Results: We observed a significant association between RPI and PC mortality in all patients (HR = 1.72, 95% CI = 1.06-2.79), as well as among overweight or obese patients (HR = 2.74, 95% 95% CI = 1.42-5.29), females (HR = 2.63; 95% CI, 1.08-6.39), and non-smokers (HR = 1.72; 95% CI, 1.02-2.89).

Conclusion: These results suggest that RPI prior to PC diagnosis is associated with a higher risk of death. Future studies with larger sample sizes are needed to explore whether this association varies across tumor histology.

Keywords: Exercise; Mortality; Pancreatic cancer; Physical activity; Survival.

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Conflict of interest statement

Conflict of interest: The authors have no conflicts of interest to disclose, including no financial supports for the research, authorship, and/or publication of this article.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curve demonstrating overall survival among patients with pancreatic cancer, by physical activity status
See this image and copyright information in PMC

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