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Review
. 2021 Jan;26(1):5-11.
doi: 10.1111/nep.13741. Epub 2020 Jul 6.

Vaccination in patients with chronic kidney disease-Review of current recommendations and recent advances

Becky Mingyao Ma  1 , Desmond Yat Hin Yap  1 , Terence Pok Siu Yip  1 , Ivan Fan Ngai Hung  2 , Sydney Chi Wai Tang  1 , Tak Mao Chan  1
Affiliations
Review

Vaccination in patients with chronic kidney disease-Review of current recommendations and recent advances

Becky Mingyao Ma et al. Nephrology (Carlton). 2021 Jan.

Abstract

Hepatitis B virus (HBV), influenza, pneumococcus and herpes zoster are important infections which could result in significant morbidity and mortality in patients with chronic kidney disease (CKD). While seroconversion rates after vaccination are often lower in CKD patients compared with healthy adults due to impaired innate and adaptive immunity, vaccinations for HBV, influenza, pneumococcus and herpes zoster are generally effective in reducing the transmission and/or severity of these infections. Practical issues that have an impact on the efficacy of vaccination in the CKD population include the timing, dose, schedule of vaccination, the route of administration, and adjuncts applied at time of vaccination. This review discusses the vaccination regimens and the efficacy of HBV, influenza, pneumococcus and zoster vaccines in CKD patients, and highlights recent advances in enhancing vaccine seroconversion rates.

Keywords: chronic kidney disease; hepatitis B; herpes zoster; influenza; invasive pneumococcal disease; vaccination.

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References

REFERENCES

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    1. Chan TM, Fang GX, Tang CS, Cheng IK, Lai KN, Ho SK. Preemptive lamivudine therapy based on HBV DNA level in HBsAg-positive kidney allograft recipients. Hepatology. 2002;36:1246-1252.
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    1. Krueger KM, Ison MG, Ghossein C. Practical guide to vaccination in all stages of CKD, including patients treated by dialysis or kidney transplantation. Am J Kidney Dis. 2020;75(3):417-425.

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