Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Sep;8(8):2777-2779.e1.
doi: 10.1016/j.jaip.2020.05.046. Epub 2020 Jun 7.

Acute generalized exanthematous pustulosis induced by hydroxychloroquine prescribed for COVID-19

Jérémie Delaleu  1 , Benjamin Deniau  2 , Maxime Battistella  3 , Adèle de Masson  1 , Benoit Bensaid  4 , Marie Jachiet  5 , Ingrid Lazaridou  5 , Martine Bagot  1 , Jean-David Bouaziz  6 ; Saint-Louis CORE (COvid REsearch) group
Collaborators, Affiliations
Case Reports

Acute generalized exanthematous pustulosis induced by hydroxychloroquine prescribed for COVID-19

Jérémie Delaleu et al. J Allergy Clin Immunol Pract. 2020 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Anamnestic, clinical, and biological features of the patient. AGEP, Acute generalized exanthematous pustulosis; ALT, alanine aminotransferase; ARDS, acute respiratory distress syndrome; BAL, bronchoalveolar lavage; BSA, body surface area; CRP, C-reactive protein; Eo, eosinophil count; HCQ, hydroxychloroquine; IL-6, interleukin-6; IV, intravenous; L, lymphocyte count; Mo, monocyte count; MV, mechanical ventilation; N, normal range; NC, neutrophil count; PCR, polymerase chain reaction; PCT, procalcitonin; PO, per-os; SC, subcutaneous; Tg, triglycerides; VCZ, voriconazole; WBC, white blood cells.
Figure 2
Figure 2
Clinical and pathological presentation of AGEP induced by HCQ. A-C, Several small pustules arising on a widespread erythema with typical flexural accentuation of AGEP. D, Histopathological features of the skin biopsy include spongiform subcorneal and intracorneal neutrophilic pustule, acanthosis, neutrophilic exocytosis, and rare necrotic keratinocytes (hematoxylin and eosin, ×180 magnification). AGEP, Acute generalized exanthematous pustulosis; HCQ, hydroxychloroquine.
See this image and copyright information in PMC

References

    1. Sidoroff A., Halevy S., Bavinck J.N., Vaillant L., Roujeau J.C. Acute generalized exanthematous pustulosis (AGEP)—a clinical reaction pattern. J Cutan Pathol. 2001;28:113–119. - PubMed
    1. Zhou P., Liu Z., Chen Y., Xiao Y., Huang X., Fan X.-G. Bacterial and fungal infections in COVID-19 patients: a matter of concern [published online ahead of print April 22, 2020] Infect Control Hosp Epidemiol. - DOI - PMC - PubMed
    1. İslamoğlu Z.G.K., Karabağli P. A case of recalcitrant acute generalized exanthematous pustulosis with Sjogren’s syndrome: successfully treated with low-dose cyclosporine. Clin Case Rep. 2019;7:1721–1724. - PMC - PubMed
    1. Mohaghegh F., Jelvan M., Rajabi P. A case of prolonged generalized exanthematous pustulosis caused by hydroxychloroquine—literature review. Clin Case Rep. 2018;6:2391–2395. - PMC - PubMed
    1. Sharma A.N., Mesinkovska N.A., Paravar T. Characterizing the adverse dermatologic effects of hydroxychloroquine: a systematic review. J Am Acad Dermatol. 2020;83:563–578. - PubMed

Publication types