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Clinical Trial
. 1988 Nov;32(11):1740-1.
doi: 10.1128/AAC.32.11.1740.

Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers

D L Dworzack  1 , C C Sanders, E A Horowitz, J M Allais, M Sookpranee, W E Sanders Jr, F M Ferraro
Affiliations
Clinical Trial

Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers

D L Dworzack et al. Antimicrob Agents Chemother. 1988 Nov.

Abstract

The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized, double-blinded study. Cultures of specimens taken from all 23 ciprofloxacin-dosed subjects 1 day postdose were negative; cultures from 96% of these subjects were negative at 7 and 21 days postdose, including a specimen from a subject colonized with a minocycline-resistant strain. Of 22 placebo recipients, 20 (91%) remained culture positive. Single-dose ciprofloxacin appears efficacious for meningococcal prophylaxis.

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References

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    1. Antimicrob Agents Chemother. 1987 Jun;31(6):962-3 - PubMed
    1. J Infect Dis. 1988 Apr;157(4):852-3 - PubMed
    1. Lancet. 1988 Jun 4;1(8597):1239-42 - PubMed
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