Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 12;5(1):77.
doi: 10.1038/s41392-020-0162-6.

Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma

Xin-Ying Xue #  1   2   3 , Yu-Xia Liu #  4 , Chen Wang #  5 , Xin-Jin Gu #  6 , Zhi-Qiang Xue  7 , Xue-Lei Zang  8 , Xi-Dong Ma  3 , Hui Deng  1 , Rong Liu  9 , Lei Pan  10 , San-Hong Liu  11
Affiliations

Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma

Xin-Ying Xue et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
a Transmission electron micrograph of exosomes from CCA and GBC patients. b Annotations of the exosomal small RNAs of normal individuals, CCA patients, and GBC patients. c Nucleotide preference of the exosomal small RNAs of normal individuals, CCA patients, and GBC patients. d Volcano map showing differentially expressed miRNAs in CCA- and GBC-derived exosomes. e Venn diagram showing overlapping differentially expressed miRNAs in CCA- and GBC-derived exosomes. f Expression levels of miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in plasma from 40 healthy individuals and 45 CCA patients. g ROC curve analysis for CCA diagnosis. Area under the curve (AUC) estimation for miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in CCA patients and healthy individuals. h Expression levels of miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in plasma from 45 CCA patients according to their tumor stage. i Changes in the plasma levels of miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in 45 CCA patients before (pre-Op) and 7 days after (7 days post-Op) surgical removal of the tumor
See this image and copyright information in PMC

References

    1. Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-mediated metastasis: communication from a distance. Dev. Cell. 2019;49:347–360. doi: 10.1016/j.devcel.2019.04.011. - DOI - PubMed
    1. Becker A, et al. Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. Cancer Cell. 2016;30:836–848. doi: 10.1016/j.ccell.2016.10.009. - DOI - PMC - PubMed
    1. Wang C, Jing Q. Non-coding RNAs as biomarkers for acute myocardial infarction. Acta Pharm. Sin. 2018;39:1110–1119. doi: 10.1038/aps.2017.205. - DOI - PMC - PubMed
    1. Chen X, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008;18:997–1006. doi: 10.1038/cr.2008.282. - DOI - PubMed
    1. Ashai N, Prasad P, Rajdev L. Multimodality management of localized biliary cancer. Curr. Treat. Options Oncol. 2019;20:58. doi: 10.1007/s11864-019-0655-0. - DOI - PubMed

Publication types