Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr 28:9:F1000 Faculty Rev-299.
doi: 10.12688/f1000research.21809.1. eCollection 2020.

Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model

Bagdeser Akdogan-Ozdilek  1 , Katherine L Duval  1 , Mary G Goll  1
Affiliations
Review

Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model

Bagdeser Akdogan-Ozdilek et al. F1000Res. .

Abstract

Early animal development is characterized by intense reorganization of the embryonic genome, including large-scale changes in chromatin structure and in the DNA and histone modifications that help shape this structure. Particularly profound shifts in the chromatin landscape are associated with the maternal-to-zygotic transition, when the zygotic genome is first transcribed and maternally loaded transcripts are degraded. The accessibility of the early zebrafish embryo facilitates the interrogation of chromatin during this critical window of development, making it an important model for early chromatin regulation. Here, we review our current understanding of chromatin dynamics during early zebrafish development, highlighting new advances as well as similarities and differences between early chromatin regulation in zebrafish and other species.

Keywords: DNA methylation; chromatin; histones; maternal-to-zygotic transition; transcription; zebrafish.

PubMed Disclaimer

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. DNA methylation and histone modifications at transcriptionally active and repressed sequences.
Figure 2.
Figure 2.. Dynamic changes in DNA methylation, histone modifications, and chromatin structure during early zebrafish development.
hpf, hours post fertilization.
See this image and copyright information in PMC

References

    1. Balasubramanian S, Raghunath A, Perumal E: Role of epigenetics in zebrafish development. Gene. 2019;718:144049. 10.1016/j.gene.2019.144049 - DOI - PubMed
    1. Horsfield JA: Packaging development: How chromatin controls transcription in zebrafish embryogenesis. Biochem Soc Trans. 2019;47(2):713–24. 10.1042/BST20180617 - DOI - PubMed
    1. Kimmel CB, Ballard WW, Kimmel SR, et al. : Stages of embryonic development of the zebrafish. Dev Dyn. 1995;203(3):253–310. 10.1002/aja.1002030302 - DOI - PubMed
    1. Kane DA, Kimmel CB: The zebrafish midblastula transition. Development. 1993;119(2):447–56. - PubMed
    1. Sansam CG, Goins D, Siefert JC, et al. : Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation. Genes Dev. 2015;29(5):555–66. 10.1101/gad.246827.114 - DOI - PMC - PubMed

Publication types

LinkOut - more resources