Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Aug;26(4):605-606.
doi: 10.1007/s13365-020-00858-9. Epub 2020 Jun 11.

Miller Fisher syndrome diagnosis and treatment in a patient with SARS-CoV-2

Affiliations
Case Reports

Miller Fisher syndrome diagnosis and treatment in a patient with SARS-CoV-2

Paolo Manganotti et al. J Neurovirol. 2020 Aug.

Abstract

This case report describes the clinical characteristics of a 50-year-old woman that developed SARS-CoV-2 pneumonia and was admitted at the COVID-19 dedicated unit where she developed neurological symptoms 10 days after admission. After neurological examination, including a panel of blood cerebrospinal fluid biomarkers, a diagnosis of Miller Fisher syndrome (MFS) was hypothesized and intravenous immunoglobulin therapy (IVIG) was initiated. Fourteen days after the start of IVIG treatment, the patient has been discharged at home with the resolution of respiratory symptoms and only minor hyporeflexia at the lower limbs, without any side effect.

Keywords: COVID-19; Cranial polyneuritis; Immunoglobulins; Miller Fisher syndrome.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interests.

References

    1. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020;11:995–998. doi: 10.1021/acschemneuro.0c00122. - DOI - PubMed
    1. Polo A, Manganotti P, Zanette G, De Grandis D. Polyneuritis cranialis: clinical and electrophysiological findings. J Neurol Neurosurg Psychiatry. 1992;55:398–400. doi: 10.1136/jnnp.55.5.398. - DOI - PMC - PubMed
    1. Pusch E, Renz H, Skevaki C. Respiratory virus-induced heterologous immunity: part of the problem or part of the solution? Allergo J Int. 2018;27:79–96. doi: 10.1007/s40629-018-0056-0. - DOI - PMC - PubMed
    1. Sellers SA, Hagan RS, Hayden FG, Fischer WA., 2nd The hidden burden of influenza: a review of the extra-pulmonary complications of influenza infection. Influenza Other Respir Viruses. 2017;11:372–393. doi: 10.1111/irv.12470. - DOI - PMC - PubMed
    1. Wakerley BR, Uncini A, Yuki N. Guillain-Barré and Miller Fisher syndromes--new diagnostic classification. Nat Rev Neurol. 2014;10:537–544. doi: 10.1038/nrneurol.2014.138. - DOI - PubMed

Publication types

Substances

LinkOut - more resources