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. 2021 Jan;60(1):93-98.
doi: 10.1111/ijd.14996. Epub 2020 Jun 12.

Primary cutaneous carcinosarcoma: clinical, histological, and immunohistochemical analysis of eight cases

Fernando García-Souto  1 , José Juan Pereyra-Rodriguez  2 , Rocío Cabrera-Perez  3 , Antonio José Durán-Romero  2 , Jerónimo Escudero-Ordoñez  1 , Julián Conejo-Mir  2
Affiliations

Primary cutaneous carcinosarcoma: clinical, histological, and immunohistochemical analysis of eight cases

Fernando García-Souto et al. Int J Dermatol. 2021 Jan.

Abstract

Background: Cutaneous carcinosarcoma is a rare biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Data on the clinical and histopathologic characteristics of this tumor are scarce. The objective of this study was to describe the clinicopathologic and immunohistochemical features of cutaneous carcinosarcoma.

Methods: A descriptive retrospective study was conducted in a tertiary care hospital from Spain. We reviewed the records of eight patients with cutaneous carcinosarcoma who were diagnosed from 2009 to 2019.

Results: The mean patient age at diagnosis was 72.13 years (range 44-91 years), and there was a male predilection (6 cases). The most common site of cutaneous carcinosarcoma was the head and neck (5 cases). Carcinosarcomas demonstrated variable histopathological and immunohistochemical features. Follow-up was available for 7-8 patients. There were two cases of local recurrence and one case of metastasis. Two patients died from the tumor during the entire follow-up.

Conclusions: Although the number of cases in this study was limited, our results provide valuable insight into the clinical, histopathologic, and immunohistochemical characteristics of primary cutaneous carcinosarcoma.

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References

    1. Müller CSL, Pföhler C, Schiekofer C, et al. Primary cutaneous carcinosarcomas: a morphological histogenetic concept revisited. Am J Dermatopathol 2014; 36: 328-339.
    1. Virchow RLK. Die Krankhaften Geschwuiste. vol. 2. Berlin: Hirschwalk, 1864: 18.
    1. Dawson EK. Carcino-sarcoma of the skin. J R Coll Surg Edinb 1972; 17: 243-246.
    1. Pang A, Carbini M, Moreira AL, Maki RG. Carcinosarcomas and related cancers: tumors caught in the act of epithelial-mesenchymal transition. J Clin Oncol 2018; 36: 210-216.
    1. Syme-Grant J, Syme-Grant NJ, Motta L, et al. Are primary cutaneous carcinisarcomas underdiagnosed? Five cases and a review of the literature. J Plast Reconstr Aesthetic Surg 2006; 59: 1402-1408.

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