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. 2020 Nov;92(11):2751-2757.
doi: 10.1002/jmv.26168. Epub 2020 Jun 29.

Clinical outcomes of 402 patients with COVID-2019 from a single center in Wuhan, China

Yingjie Wu  1 , Wei Guo  1   2 , Huan Liu  1 , Bei Qi  1 , Ke Liang  3 , Haibo Xu  4 , Zhiyong Peng  5 , Shu-Yuan Xiao  1   6
Affiliations

Clinical outcomes of 402 patients with COVID-2019 from a single center in Wuhan, China

Yingjie Wu et al. J Med Virol. 2020 Nov.

Abstract

The outbreak of SARS-CoV-2 has become a pandemic with significant mortality. Published studies described clinical characteristics of the disease contain small cohorts from individual centers or larger series consisting of mixed series from multiple different hospitals. We report here analyses of mortality and disease severity among 402 patients from a single hospital. The cohort includes 297 patients with confirmed and 105 with clinical diagnosis. The latter group consists of cases with inconclusive nucleic acid test but meeting the criteria for clinical diagnosis. Data are compared between sexes and among different age groups. The overall case fatality is 5.2%. However, age at 70 years or older is associated with a significantly higher mortality (17.8%) and higher rate of severe and critical illness (57.5%). Case fatality is 8% in patients 50 years of age or older, and 1.2% in those younger than 50 years. In addition, case fatality is 7.6% in male patients, as opposed to 2.9% in females, demonstrating a clear sex difference.

Keywords: COVID-19; SARS-CoV-2; coronavirus; diagnosis; epidemiology; fatality; mortality.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Case fatality analysis of COVID‐19 patients. A, Fatality of confirmed and suspected cases. B, Fatality by male and female sex for suspected and confirmed cases. C, Fatality by male and female sex for confirmed cases only. D, Fatality by age groups for suspected and confirmed cases. E, Fatality by age group for confirmed cases only. *P < .05; ***P < .001
Figure 2
Figure 2
Clinical severity classification among COVID‐19 patients by sex and age groups. A, Overall severity classification in all cases vs confirmed cases. B, Severity classification in male vs female sex for all cases. C, Severity classification in male vs female sex for confirmed cases. D, Severity classification by age groups for all cases. E, Severity classification by age for confirmed cases. ns. no significance; *P < .05, **P < .01
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