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Review
. 2020 Jul;53(7):e12822.
doi: 10.1111/cpr.12822. Epub 2020 Jun 12.

A review on methods for diagnosis of breast cancer cells and tissues

Ziyu He  1 , Zhu Chen  1   2 , Miduo Tan  3 , Sauli Elingarami  4 , Yuan Liu  1   2 , Taotao Li  5 , Yan Deng  1 , Nongyue He  1   2 , Song Li  1 , Juan Fu  6 , Wen Li  1
Affiliations
Review

A review on methods for diagnosis of breast cancer cells and tissues

Ziyu He et al. Cell Prolif. 2020 Jul.

Abstract

Breast cancer has seriously been threatening physical and mental health of women in the world, and its morbidity and mortality also show clearly upward trend in China over time. Through inquiry, we find that survival rate of patients with early-stage breast cancer is significantly higher than those with middle- and late-stage breast cancer, hence, it is essential to conduct research to quickly diagnose breast cancer. Until now, many methods for diagnosing breast cancer have been developed, mainly based on imaging and molecular biotechnology examination. These methods have great contributions in screening and confirmation of breast cancer. In this review article, we introduce and elaborate the advances of these methods, and then conclude some gold standard diagnostic methods for certain breast cancer patients. We lastly discuss how to choose the most suitable diagnostic methods for breast cancer patients. In general, this article not only summarizes application and development of these diagnostic methods, but also provides the guidance for researchers who work on diagnosis of breast cancer.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of MRI
Figure 2
Figure 2
Technical principle of fluorescence in situ hybridization
Figure 3
Figure 3
Schematics of cell‐based aptamer selection. 147 (Reproduced with permission from Copyright 2014, American Chemical Society)
Figure 4
Figure 4
Flow chart of microarray technology. 162 (Reproduced with permission from Copyright 2012, Rajnish Kumar)
Figure 5
Figure 5
Schematic diagram for NGS
Figure 6
Figure 6
Schematic diagram of MethyLight
Figure 7
Figure 7
Schematic diagram of immunohistochemical principle
Figure 8
Figure 8
Isolation of individual droplets by flow cytomtry. 121 (Reproduced with permission from Copyright 2020, American Chemical Society)
See this image and copyright information in PMC

References

    1. DeSantis CE, Ma J, Gaudet MM, et al. Breast cancer statistics, 2019. CA Cancer J Clin. 2018;69(6):438‐451. - PubMed
    1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115‐132. - PubMed
    1. Feng R‐M, Zong Y‐N, Cao S‐M, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer Commun. 2019;29(1):22. - PMC - PubMed
    1. Tao ZQ, Shi A, Lu C, et al. Breast cancer: epidemiology and etiology. Cell Biochem Biophys. 2015;72(2):333‐338. - PubMed
    1. DeSantis CE, Ma J, Jemal A. Trends in stage at diagnosis for young breast cancer patients in the United States. Breast Cancer Res Treat. 2019;173(3):743‐747. - PubMed