Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jul 13;38(1):23-24.
doi: 10.1016/j.ccell.2020.05.021. Epub 2020 Jun 11.

Pan-Cancer Early Detection: Hype or Hope?

Affiliations
Free article
Comment

Pan-Cancer Early Detection: Hype or Hope?

Sudhir Srivastava et al. Cancer Cell. .
Free article

Abstract

Universal cancer screening based on circulating DNA, proteins, metabolites, or other combinations has the potential to revolutionize early cancer detection, especially for cancers with no available screening modalities. Two recent publications in Science and Annals of Oncology highlight the potential benefits and limitations of single-test, multiple cancer screens.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests S.H. has IP filings related to pancreatic cancer and lung cancer biomarkers with applications to cancer detection. One IP filing was licensed to Thrive Technologies (one author of Lennon et al., 2020 is affiliated with Thrive Technologies).

Comment on

  • Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.
    Lennon AM, Buchanan AH, Kinde I, Warren A, Honushefsky A, Cohain AT, Ledbetter DH, Sanfilippo F, Sheridan K, Rosica D, Adonizio CS, Hwang HJ, Lahouel K, Cohen JD, Douville C, Patel AA, Hagmann LN, Rolston DD, Malani N, Zhou S, Bettegowda C, Diehl DL, Urban B, Still CD, Kann L, Woods JI, Salvati ZM, Vadakara J, Leeming R, Bhattacharya P, Walter C, Parker A, Lengauer C, Klein A, Tomasetti C, Fishman EK, Hruban RH, Kinzler KW, Vogelstein B, Papadopoulos N. Lennon AM, et al. Science. 2020 Jul 3;369(6499):eabb9601. doi: 10.1126/science.abb9601. Epub 2020 Apr 28. Science. 2020. PMID: 32345712 Free PMC article.
  • Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.
    Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium. Liu MC, et al. Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016/j.annonc.2020.02.011. Epub 2020 Mar 30. Ann Oncol. 2020. PMID: 33506766 Free PMC article.

LinkOut - more resources