Pan-Cancer Early Detection: Hype or Hope?
- PMID: 32531269
- DOI: 10.1016/j.ccell.2020.05.021
Pan-Cancer Early Detection: Hype or Hope?
Abstract
Universal cancer screening based on circulating DNA, proteins, metabolites, or other combinations has the potential to revolutionize early cancer detection, especially for cancers with no available screening modalities. Two recent publications in Science and Annals of Oncology highlight the potential benefits and limitations of single-test, multiple cancer screens.
Published by Elsevier Inc.
Conflict of interest statement
Declaration of Interests S.H. has IP filings related to pancreatic cancer and lung cancer biomarkers with applications to cancer detection. One IP filing was licensed to Thrive Technologies (one author of Lennon et al., 2020 is affiliated with Thrive Technologies).
Comment on
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Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.Science. 2020 Jul 3;369(6499):eabb9601. doi: 10.1126/science.abb9601. Epub 2020 Apr 28. Science. 2020. PMID: 32345712 Free PMC article.
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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016/j.annonc.2020.02.011. Epub 2020 Mar 30. Ann Oncol. 2020. PMID: 33506766 Free PMC article.
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