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. 2020 Aug:64:102220.
doi: 10.1016/j.anaerobe.2020.102220. Epub 2020 Jun 10.

Molecular basis of macrolide-lincosamide-streptogramin (MLS) resistance in Finegoldia magna clinical isolates

François Guérin  1 , Sabrine Lachaal  2 , Michel Auzou  1 , Cécile Le Brun  3 , Olivier Barraud  4 , Jean-Winoc Decousser  5 , Reto Lienhard  6 , Régine Baraduc  7 , Luc Dubreuil  8 , Vincent Cattoir  9
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Free article

Molecular basis of macrolide-lincosamide-streptogramin (MLS) resistance in Finegoldia magna clinical isolates

François Guérin et al. Anaerobe. 2020 Aug.
Free article

Abstract

Of 69 clinical isolates of Finegoldia magna tested, 36% presented high-level MICs of erythromycin (>256 μg/ml), harboring erm(A) (n = 20) or erm(B) (n=5). Of nine isolates exhibiting an inducible resistance phenotype to macrolides-lincosamides-streptogramins B, four (44%) were susceptible with a potential risk of treatment failure due to emergence of resistant mutants.

Keywords: F. magna; GPAC; MLS; anaerobes; clindamycin; erm(A); erm(B).

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