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Comment
. 2020 Aug 15:415:116944.
doi: 10.1016/j.jns.2020.116944. Epub 2020 May 27.

Serotonin syndrome in two COVID-19 patients treated with lopinavir/ritonavir

Miguel Mas Serrano  1 , Javier Ricardo Pérez-Sánchez  2 , Sofía Portela Sánchez  1 , Beatriz De La Casa-Fages  3 , Víctor Mato Jimeno  4 , Isabel Pérez Tamayo  4 , Francisco Grandas  3
Affiliations
Comment

Serotonin syndrome in two COVID-19 patients treated with lopinavir/ritonavir

Miguel Mas Serrano et al. J Neurol Sci. .

Abstract

  1. •

    Two cases of Serotonin syndrome (SS) in COVID-19 patients are presented.

  2. •

    Lopinavir/ritonavir (LPV/r) have been widely used during the COVID-19 pandemic.

  3. •

    LPV/r with duloxetine and lithium triggered SS in patient 1.

  4. •

    LPV/r with risperidone, and probably also morphine, triggered SS in patient 2.

  5. •

    A Video of patient 2 shows myoclonus and ocular clonus in the context of SS.

Keywords: COVID-19; Drug-induced disorder; Lopinavir/ritonavir; Neurological complication; Serotonin syndrome.

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Conflict of interest statement

Declaration of Competing Interest None.

Comment on

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