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Editorial
. 2021 Feb;109(2):281-282.
doi: 10.1002/JLB.4CE0520-256R. Epub 2020 Jun 12.

Antimicrobial zinc toxicity in Mϕs: ZnT1 pays the toll

Olivier Neyrolles  1
Affiliations
Editorial

Antimicrobial zinc toxicity in Mϕs: ZnT1 pays the toll

Olivier Neyrolles. J Leukoc Biol. 2021 Feb.

Abstract

Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB, Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contributes to zinc accumulation in Escherichia coli-containing phagosomes, resulting in increased bacterial clearance.

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References

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