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Comment
. 2020 Jun 12;5(1):94.
doi: 10.1038/s41392-020-0209-8.

Eating self for not be eaten: Pancreatic cancer suppresses self-immunogenicity by autophagy-mediated MHC-I degradation

Xing Huang  1   2 , Xiaozhen Zhang  3   4 , Xueli Bai  5   6 , Tingbo Liang  7   8
Affiliations
Comment

Eating self for not be eaten: Pancreatic cancer suppresses self-immunogenicity by autophagy-mediated MHC-I degradation

Xing Huang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Autophagy inhibition potentiates anti-pancreatic cancer immunotherapy. Tumoral MHC-I contributes to TCR-mediated antigen recognition by T cells, while PD-1–PD-L1 interaction causes T cell dysfunction and immune evasion. MHC-I is degraded by autophagy in pancreatic cancer, and thus results in deficiency of antigen presentation and consequent ineffectiveness of immunotherapy. Combination of autophagy inhibitor and PD-1/PD-L1 blockade can improve therapeutic efficacy of pancreatic cancer, showing the potential to be a promising strategy for cancer therapy
See this image and copyright information in PMC

Comment on

  • Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
    Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. Yamamoto K, et al. Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22. Nature. 2020. PMID: 32376951 Free PMC article.

References

    1. Yamamoto K, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100–105. doi: 10.1038/s41586-020-2229-5. - DOI - PMC - PubMed
    1. Maitra A. Pancreatic cancer hidden in plain sight. Nature. 2020;581:34–35. doi: 10.1038/d41586-020-01103-3. - DOI - PubMed
    1. Buscail L, Bournet B, Cordelier P. Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer. Nat. Rev. Gastroenterol. Hepatol. 2020;17:153–168. doi: 10.1038/s41575-019-0245-4. - DOI - PubMed
    1. Kinsey CG, et al. Protective autophagy elicited by RAF->MEK->ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat. Med. 2019;25:620–627. doi: 10.1038/s41591-019-0367-9. - DOI - PMC - PubMed
    1. Bryant KL, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat. Med. 2019;25:628–640. doi: 10.1038/s41591-019-0368-8. - DOI - PMC - PubMed

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