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. 2020 Oct 15:161:936-938.
doi: 10.1016/j.ijbiomac.2020.06.031. Epub 2020 Jun 11.

Antiviral activity of the high-molecular-weight plant polysaccharides (Panavir®)

Tatiana S Kalinina  1 , Dmitry V Zlenko  2 , Aleksei V Kiselev  3 , Alexander A Litvin  4 , Sergey V Stovbun  3
Affiliations

Antiviral activity of the high-molecular-weight plant polysaccharides (Panavir®)

Tatiana S Kalinina et al. Int J Biol Macromol. .

Abstract

This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum tuberosum. It demonstrates activity against many types of viruses, including animal coronavirus and also against bacterial infections. These properties look very promising considering the COVID-19 epidemy and allow propose that Panavir® would be effective in the therapy of the SARS-CoV-2 infection.

Keywords: Antiviral activity; COVID-19; Immune modulator.

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Figures

Fig. 1
Fig. 1
The dynamics of mortality of mice infected by Klebsiella pneumoniae (A) or Shigella flexneri (B) and rats suffering from fecal peritonitis (C). Experimental groups (green curves) were treated with Panavir®, while the control (red curves) – were not. In C, the results of two independent experiments are presented.
See this image and copyright information in PMC

References

    1. Stovbun S.V., Yakovenko L.V. The physicochemical basis of the biological activity and pharmacological properties of the antiviral agent Panavir. Mosc. Univ. Phys. Bull. 2014;69:542–547.
    1. Stovbun S., Berlin A., Mikhailov A., Sergienko V., Govorun V., Demina I., Kalinina T. Physicochemical properties of high-molecular-weight plant polysaccharide of hexose glycoside class (Panavir) with antiviral activity. Nanotechnologies in Russia. 2012;7:539–543.
    1. Martinez M.J.A., Olmo L.M.B.D., Benito P.B. Antiviral activities of polysaccharides from natural sources. Stud. Nat. Prod. Chem. 2005;30:393–418.
    1. Wang W., Wang S.-X., Guan H.-S. The antiviral activities and mechanisms of marine polysaccharides: an overview. Marine Drugs. 2012;10:2795–2816. - PMC - PubMed
    1. Chen L., Huang G. The antiviral activity of polysaccharides and their derivatives. Int. J. Biol. Macromol. 2018;115:77–82. - PubMed

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