Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec;9(2):293-305.
doi: 10.1007/s40119-020-00184-5. Epub 2020 Jun 13.

Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection

Gregory L Judson  1 , Benjamin W Kelemen  1 , Joyce N Njoroge  1 , Vaikom S Mahadevan  2
Affiliations
Review

Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection

Gregory L Judson et al. Cardiol Ther. 2020 Dec.

Abstract

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has profoundly impacted all fields of medicine. Infection with SARS-CoV-2 and the resulting coronavirus of 2019 (COVID-19) syndrome has multiorgan effects. The pandemic has united researchers from bench to bedside in attempts to understand the pathophysiology of the disease and define optimal treatment strategies. Cardiovascular disease is highly prevalent and a leading cause of death across gender, race, and ethnic groups. As the pandemic spreads, there is increasing concern about the cardiovascular effects of the viral infection and the interaction of infection with existing cardiovascular disease. Additionally, there are concerns about the cardiac effects of the numerous treatment agents under study. It will be essential for cardiologists to understand the interplay between underlying cardiac comorbidities, acute cardiovascular effects of COVID-19 disease, and adverse effects of new treatments. Here we describe emerging evidence of the epidemiology of SARS-CoV-2 infection and underlying cardiovascular disease, the evidence for direct myocardial injury in SARS-CoV-2 infection, the specific presentations of cardiovascular involvement by SARS-CoV-2, and the cardiac effects of emerging treatments.

Keywords: COVID-19; Cardiovascular implications; Coronavirus; SARS.

PubMed Disclaimer

Conflict of interest statement

Gregory L. Judson, Benjamin W. Kelemen, Joyce N. Njoroge, and Vaikom S. Mahadevan have nothing to disclose in relation to this article.

References

    1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. COVID-19 Map. Johns Hopkins Coronavirus Resource Center. https://coronavirus.jhu.edu/map.html. Accessed 1 Jun 2020
    1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi: 10.1016/S0140-6736(20)30566-3. - DOI - PMC - PubMed
    1. CDC. COVID-19 in Racial and Ethnic Minority Groups. Centers for disease control and prevention. Published Feb 11, 2020. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/racial-.... Accessed 1 Jun 2020
    1. Peiris JSM, Lai ST, Poon LLM, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319–1325. doi: 10.1016/s0140-6736(03)13077-2. - DOI - PMC - PubMed