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Case Reports
. 2020 Sep;62(3):E57-E60.
doi: 10.1002/mus.27003. Epub 2020 Jul 3.

COVID-19-associated myositis with severe proximal and bulbar weakness

Hui Zhang  1 , Zeinab Charmchi  1 , Roberta J Seidman  2 , Yaacov Anziska  1 , Vinodkumar Velayudhan  3 , Jonathan Perk  1
Affiliations
Case Reports

COVID-19-associated myositis with severe proximal and bulbar weakness

Hui Zhang et al. Muscle Nerve. 2020 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no potential conflicts of interest.

Figures

FIGURE 1
FIGURE 1
A and B, Sagittal T1WIs of contrast‐enhanced fat‐suppressed MRI of the paraspinal and thigh muscles demonstrate extensive edema and enhancement (yellow arrows in A) consistent with inflammatory myopathy; central nonenhancement in the vastus medialis (yellow arrow in B) is consistent with myonecrosis. C‐F, Biopsy of the left quadriceps muscle. Hematoxylin‐and‐eosin cryostat sections demonstrate multifocal, predominantly perimysial perivascular lymphocytic inflammation (C, and yellow arrows in D), with focal endomysial extension (black arrows in D). Multiple regenerating myofibers (white arrows in E) are recognized by their mild sarcoplasmic basophilia and enlargement of visible nuclei. There is upregulation of HLA class ABC on myofiber surfaces, and sarcoplasmic staining by immunohistochemistry can be identified by the brown staining of myofibers, most consistent with an inflammatory myopathy (F). Scale bar = 50 μm. HLA, human leukocyte antigen; T1WI, T1‐weighted image
See this image and copyright information in PMC

Comment in

  • Reply.
    Perk J, Anziska Y, Seidman R. Perk J, et al. Muscle Nerve. 2021 Jan;63(1):E10. doi: 10.1002/mus.27104. Epub 2020 Nov 6. Muscle Nerve. 2021. PMID: 33095466 No abstract available.
  • COVID-19-associated myositis may be dermatomyositis.
    Tanboon J, Nishino I. Tanboon J, et al. Muscle Nerve. 2021 Jan;63(1):E9-E10. doi: 10.1002/mus.27105. Epub 2020 Nov 15. Muscle Nerve. 2021. PMID: 33095493 No abstract available.

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