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Editorial
. 2020 Aug;32(8):497-500.
doi: 10.1016/j.clon.2020.06.002. Epub 2020 Jun 10.

Personal View: Low-dose Lung Radiotherapy for COVID-19 Pneumonia - The Atypical Science and the Unknown Collateral Consequence

H Tharmalingam  1 , P Díez  2 , Y Tsang  3 , A Hawksley  4 , J Conibear  5 , N Thiruthaneeswaran  6
Affiliations
Editorial

Personal View: Low-dose Lung Radiotherapy for COVID-19 Pneumonia - The Atypical Science and the Unknown Collateral Consequence

H Tharmalingam et al. Clin Oncol (R Coll Radiol). 2020 Aug.
No abstract available

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Figures

Fig 1
Fig 1
Respiratory failure in novel coronavirus disease 2019 (COVID-19) pneumonia. Severe early hypoxia mediated by a perfusion deficit secondary to viral-induced endothelial dysfunction (left panel). Patients may either recover with effective viral clearance or progress to critical acute respiratory distress syndrome (ARDS; right panel) due to unchecked viral disease, patient self-induced and/or ventilator-associated lung injury. The time course is unpredictable and the therapeutic window for low-dose radiotherapy is very narrow.
See this image and copyright information in PMC

References

    1. 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situatio...
    1. Mehta P., McAuley D.F., Brown M., Sanchez E., Tattersall R.S., Manson J.J. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–1034. - PMC - PubMed
    1. Calabrese E.J., Dhawan G. How radiotherapy was historically used to treat pneumonia: could it be useful today? Yale J Biol Med. 2013;86:555–570. - PMC - PubMed
    1. Arenas M., Sabater S., Hernández V., Rovirosa A., Lara P.C., Biete A. Anti-inflammatory effects of low-dose radiotherapy. Indications, dose and radiobiological mechanisms involved. Strahlenther Onkol. 2015;191(1):1–6. - PubMed
    1. https://clinicaltrials.gov/ct2/show/NCT04380818.

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