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Case Reports
. 2022 Jul 1;16(4):466-469.
doi: 10.1097/ICB.0000000000001009.

ACUTE ZONAL OCCULT OUTER RETINOPATHY: A CASE REPORT OF REGRESSION AFTER AN INTRAVITREAL DEXAMETHASONE (OZURDEX) IMPLANT

Julie Vadboncoeur  1 , Lee M Jampol, Debra A Goldstein
Affiliations
Case Reports

ACUTE ZONAL OCCULT OUTER RETINOPATHY: A CASE REPORT OF REGRESSION AFTER AN INTRAVITREAL DEXAMETHASONE (OZURDEX) IMPLANT

Julie Vadboncoeur et al. Retin Cases Brief Rep. .

Abstract

Purpose: To report the use of the dexamethasone (Ozurdex, Allergan Inc) intravitreal implant in the management of acute zonal occult outer retinopathy.

Methods: Observational case report.

Results: A 63-year-old woman presented with a 10-year history of progressing bilateral, although asymmetric, visual impairment and scotomata with clinical and imaging findings compatible with acute zonal occult outer retinopathy. The right eye had recently progressed rapidly until macular involvement occurred with loss of visual acuity. Under our observation, progression toward the fovea in the left eye occurred, Ozurdex intravitreal implant treatment was offered and administered. Autofluorescence imaging documented resolution of the hyperautofluorescent borders and slight regression of the involved retina. An injection was repeated every 6 months for 3 injections, and after a follow-up period, 20 months after the first and 8 months after the last injection, no further signs of progression were observed in her left eye.

Conclusion: The dexamethasone implant effectively achieved regression of active disease in a patient with longstanding, progressive acute zonal occult outer retinopathy.

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References

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Supplementary concepts