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Meta-Analysis
. 2020 Jun 12;99(24):e20689.
doi: 10.1097/MD.0000000000020689.

Efficacy of intra-articular polynucleotides associated with hyaluronic acid vs hyaluronic acid alone in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trial

Lei Zhang  1 , Ningbo Lei, Ruilong Chang, Chenxu Yang, Qiang Li, Ning Zuo, Yubiao Gu
Affiliations
Meta-Analysis

Efficacy of intra-articular polynucleotides associated with hyaluronic acid vs hyaluronic acid alone in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trial

Lei Zhang et al. Medicine (Baltimore). .

Erratum in

  • Study Protocol Titles: Erratum.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2020 Aug 14;99(33):e21984. doi: 10.1097/MD.0000000000021984. Medicine (Baltimore). 2020. PMID: 32872085 Free PMC article. No abstract available.

Abstract

Background: The reduced range of motion and pain are the most characteristic clinical features of osteoarthritis (OA). Hyaluronic acid (HA), which is one of the infiltrative therapies for OA treatment, and polynucleotides (PNs), which is a DNA-derived macromolecule favored cell growth and collagen production, are an ongoing debate in clinical effectiveness.

Methods: We plan to perform a systematic review and meta-analysis of randomized clinical trial to evaluate efficacy of intra-articular polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis. We will search PubMed, EMBASE, Cochrane Library using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis.

Results: This study will be submitted to a peer-reviewed journal for publication.

Conclusion: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials.

Ethics and dissemination: Ethics approval and patient consent are not required, as this study is a systematic review and meta-analysis.

Prospero registration number: CRD42020167678.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

References

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