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. 2020 Jun 12;99(24):e20752.
doi: 10.1097/MD.0000000000020752.

Dose-response of rPMS for upper Limb hemiparesis after stroke

Shoji Kinoshita  1 , Kumi Ikeda  1 , Shinji Yasuno  2 , Sho Takahashi  2 , Naoki Yamada  1 , Yumi Okuyama  1 , Nobuyuki Sasaki  1 , Takuya Hada  1 , Chiaki Kuriyama  1 , Shin Suzuki  1 , Midori Hama  1 , Naoto Ozaki  1 , Shu Watanabe  1 , Masahiro Abo  1
Affiliations

Dose-response of rPMS for upper Limb hemiparesis after stroke

Shoji Kinoshita et al. Medicine (Baltimore). .

Abstract

Introduction: Repetitive peripheral magnetic stimulation (rPMS) therapy is an innovative and minimally invasive neurorehabilitative technique and has been shown to facilitate neural plasticity. However, there is at present no research that clarifies the dose-response of rPMS therapy on the recovery of upper limb hemiparesis after stroke. This trial aims to clarify the dose-response of rPMS therapy combined with intensive occupational therapy (OT) for chronic stroke patients with moderate to severe upper limb hemiparesis.

Methods and analysis: This multicenter, prospective, assessor-blinded, randomized controlled study with 3 parallel groups will be conducted from January 20, 2020 to September 30, 2022. Fifty patients will be randomly assigned in a ratio of 1:2:2 to the control group, the group receiving daily 2400 pulses of rPMS, or the group receiving daily 4800 pulses of rPMS, respectively. From the day after admission (Day 1), rPMS therapy and intensive OT will be initiated. The primary outcome is the change in the motor function of the affected upper extremity (Fugl-Meyer Assessment) between the time of admission (Day 0) and the day after 2 weeks of treatment (Day 14). Secondary outcomes will include the changes in spasticity, active range of motion, motor evoked potential, and activity of daily living.

Ethics and dissemination: The study was approved by the Jikei University Certified Review Board for all institutions (reference number: JKI19-020). Results of the primary and secondary outcomes will be published in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to patients.

Trial registration number: jRCTs032190191.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Study flow chart.
Figure 2
Figure 2
Photograph illustrating the application of repetitive peripheral magnetic stimulation (rPMS) therapy using a parabolic coil. Sufficient stimulation of the deep layer of muscles is possible by applying the rPMS even through the clothes.
See this image and copyright information in PMC

References

    1. Nichols-Larsen D, Clark P, Zeringue A, et al. Factors influencing stroke survivors’ quality of life during subacute recovery. Stroke 2005;36:1480–4. - PubMed
    1. Howlett O, Lannin N, Ada L, et al. Functional electrical stimulation improves activity after stroke: a systematic review with meta-analysis. Arch Phys Med Rehabil 2015;96:934–43. - PubMed
    1. Yang J, Liao C, Huang S, et al. Effectiveness of electrical stimulation therapy in improving arm function after stroke: a systematic review and a meta-analysis of randomised controlled trials. Clin Rehabil 2019;33:1286–97. - PubMed
    1. Abo M, Kakuda W, Momosaki R, et al. Randomized, multicenter, comparative study of NEURO versus CIMT in poststroke patients with upper limb hemiparesis: The NEURO-VERIFY Study. Int J Stroke 2014;9:607–12. - PubMed
    1. Lefaucheur J, André-Obadia N, Antal A, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol 2014;125:2150–206. - PubMed

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