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Case Reports
. 2020 May 13;12(5):e8092.
doi: 10.7759/cureus.8092.

Resolution of Keratoacanthoma Type Squamous Cell Carcinoma Following Intralesional Therapy With Methotrexate

Andrea Sisti  1 , Maria T Huayllani  2 , Daniel Boczar  2 , Scott Fosko  3 , Antonio J Forte  2
Affiliations
Case Reports

Resolution of Keratoacanthoma Type Squamous Cell Carcinoma Following Intralesional Therapy With Methotrexate

Andrea Sisti et al. Cureus. .

Abstract

Keratoacanthoma is considered a variant of squamous cell carcinoma prone to spontaneous involution, but it may also rapidly grow and invade surrounding tissues. Herein, we report a case of keratoacanthoma-type squamous cell carcinoma that resolved after intralesional therapy with methotrexate.

Keywords: keratoacanthoma; methotrexate; squamous cells carcinoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Pre- and post-treatment pictures.
(A, B) Pre-treatment pictures. The arrow shows lesion in the first digit of the right hand. (C, D) After three methotrexate injections (three months after the first methotrexate intralesional treatment). The arrow shows the lesion completely disappeared.
Figure 2
Figure 2. Radiography of the right hand. No bone involvement is observed.
See this image and copyright information in PMC

References

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