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. 2020 Jun 11;6(6):1327-1339.
doi: 10.1016/j.chempr.2020.05.013.

Developments in Photoredox/Nickel Dual-Catalyzed 1,2-Difunctionalizations

Shorouk O Badir  1 , Gary A Molander  1
Affiliations

Developments in Photoredox/Nickel Dual-Catalyzed 1,2-Difunctionalizations

Shorouk O Badir et al. Chem. .

Abstract

Progress in Ni/photoredox dual catalysis has enabled the construction of C(sp3)-hybridized centers under extremely mild reaction conditions in the presence of diverse functional groups. These strategies, however, are mainly restricted to the assembly of one C-C or C-heteroatom linkage because of the competitive two-component reactions and facile β-hydride elimination from alkylmetal complexes. Recently, photoinduced nickel-catalyzed 1,2-difunctionalizations of alkenes and alkynes have attracted extensive research efforts as they allow the construction of two sequential chemical bonds from inexpensive starting materials in one pot. Herein, we explore recent advances, state the current challenges, and discuss perspectives on the design of new catalytic systems.

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Figures

Figure 1.
Figure 1.
Dual photoredox and nickel-catalyzed 1,2-difunctionalizations.
Figure 2.
Figure 2.
Three-component carbodifunctionalization of vinyl boronates.
Figure 3.
Figure 3.
Asymmetric acyl-carbamoylation of alkenes.
Figure 4.
Figure 4.
Amidoarylation of unactivated olefins.
Figure 5.
Figure 5.
Three-component carbodifunctionalization of alkynes.
See this image and copyright information in PMC

References

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