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Case Reports

. 2020 Nov;33(6):e13834.

doi: 10.1111/dth.13834. Epub 2020 Jul 8.

Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19

Tyler Enos¹, Haneol S Jeong¹, Travis Vandergriff¹, Heidi T Jacobe¹, Benjamin F Chong¹

Affiliations

PMID: 32542893
PMCID: PMC7323399
DOI: 10.1111/dth.13834

Case Reports

Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19

Tyler Enos et al. Dermatol Ther. 2020 Nov.

. 2020 Nov;33(6):e13834.

doi: 10.1111/dth.13834. Epub 2020 Jul 8.

Authors

Tyler Enos¹, Haneol S Jeong¹, Travis Vandergriff¹, Heidi T Jacobe¹, Benjamin F Chong¹

Affiliation

¹ Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

PMID: 32542893
PMCID: PMC7323399
DOI: 10.1111/dth.13834

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no potential conflict of interest.

Figures

FIGURE 1
Patient's Rash. Red‐pink erythematous papules and non‐follicular pustules involving, A, face and B, abdomen. C, Close up of pinpoint pustules. Informed consent was obtained from the patient to publish these photos

FIGURE 2
Skin biopsy pathology. A, Hematoxylin‐eosin stained punch biopsy from the abdomen showing a ruptured subcorneal pustule (100× magnification); B, with neutrophils and eosinophils consistent with acute generalized exanthematous pustulosis (400× magnification)

See this image and copyright information in PMC

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References

1. Szatkowsk J, Schwartz RA. Acute generalized exanthematous pustulosis (AGEP): a review and update. J Am Acad Dermatol. 2015;73:843‐848. - PubMed
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1. Sharma AN, Mesinkovska NA, Paravar T. Characterizing the adverse dermatologic effects of hydroxychloroquine: a systematic review. J Am Acad Dermatol. 2020;S0190‐9622(20)30564‐8 [published online ahead of print, 2020 Apr 11]. 10.1016/j.jaad.2020.04.02. - DOI - PubMed
1. Castner NB, Harris JC, Motaparthi K. Cyclosporine for corticosteroid‐refractory acute generalized exanthematous pustulosis due to hydroxychloroquine. Dermatol Ther. 2018;31(5):e12660. - PubMed
1. Pearson KC, Morrell DS, Runge SR, Jolly P. Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis. Cutis. 2016;97(3):212‐216. - PubMed

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