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Review
. 2020 Aug:217:108510.
doi: 10.1016/j.clim.2020.108510. Epub 2020 Jun 13.

Development of child immunity in the context of COVID-19 pandemic

Małgorzata Kloc  1 , Rafik M Ghobrial  2 , Ernest Kuchar  3 , Sławomir Lewicki  4 , Jacek Z Kubiak  5
Affiliations
Review

Development of child immunity in the context of COVID-19 pandemic

Małgorzata Kloc et al. Clin Immunol. 2020 Aug.

Abstract

Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children.

Keywords: COVID-19; Child immunity; Immune system development; Macrophages.

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References

    1. Guleria I., Sayegh M.H. Maternal acceptance of the Fetus: true human tolerance. J. Immunol. 2007;178(6):3345–3351. doi: 10.4049/jimmunol.178.6.3345. - DOI - PubMed
    1. Simon A.K., Hollander G.A., McMichael A. Evolution of the immune system in humans from infancy to old age. Proc. Biol. Sci. 2015;282(1821):20143085. doi: 10.1098/rspb.2014.3085. - DOI - PMC - PubMed
    1. Schüller S.S., Sadeghi K., Wisgrill L., Dangl A., Diesner S.C., Prusa A.R., Klebermasz-Schrehof K., Greber-Platzer S., Neumüller J. Preterm neonates display altered plasmacytoid dendritic cell function and morphology. J. Leukoc. Biol. 2013;93:781–788. doi: 10.1189/jlb.1011525. - DOI - PubMed
    1. Cristiani L., Mancino E., Matera L., Nenna R., Pierangeli A., Scagnolari C., Midulla F. Will children reveal their secret? The coronavirus dilemma. Eur Respir J. 2020:2000749. doi: 10.1183/13993003.00749-2020. Apr 2. - DOI - PMC - PubMed
    1. Myśliwska J., Trzonkowski P., Szmit E. Immunomodulating effect of influenza vaccination in the elderly differing in health status. Exp. Gerontol. 2004;39:1447–1458. doi: 10.1016/j.exger.2004.08.005. - DOI - PubMed

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