Pembrolizumab in relapsed or refractory Richter syndrome
- PMID: 32544980
- PMCID: PMC7496875
- DOI: 10.1111/bjh.16762
Pembrolizumab in relapsed or refractory Richter syndrome
Keywords: PD-1; Richter syndrome; chronic lymphocytic leukaemia; immunotherapy; pembrolizumab.
Conflict of interest statement
PA: Consultancy, research funding (institution) and personal fees from Merck and Bristol‐Myers Squibb during the conduct of the study; consultancy outside the submitted work for Pfizer, Affimed, Adaptive, Infinity, ADC Therapeutics, Celgene, Morphosys, Daiichi Sankyo, Miltenyi, Tessa, C4, GenMab; research funding outside the submitted work from Affimed, Adaptive, Roche, Tensha, Otsuka, Sigma Tau, Genentech, IGM. NM: No conflicts to disclose. DM: Clinical study support from Merck during the conduct of the study; personal fees (lectures) from Roche, Takeda, Merck and Bristol‐Myers Squibb outside the submitted work. JZ: Consultancy role with Seattle Genetics, Mundi Pharma , Verastem and Kyowa Kirin; member of a speaker's bureau for Seattle Genetics and Spectrum. BE: Grants from Janssen, Roche, AbbVie, Gilead and BeiGene; personal fees from Janssen, Roche, Novartis, Gilead, Celgene, AstraZeneca, Oxford Biomedica (UK), Adaptive Biotechnologies and ArQule. ZG: No conflicts to disclose. EH: Research funding/grants from Merck, AstraZeneca, Bristol‐Myers Squibb, Celgene, Merck Serono; personal advisory board fees from AstraZeneca; advisory board payment to institution from Merck, Roche and Gilead. JMP: personal fees from Gilead, Pharmacyclics and AstraZeneca. TP: No conflicts to disclose. VR: Non‐financial research funding from ArgenX; personal fees (advisory board) from Gilead, Infinity, Merck, Bristol‐Myers Squibb, Epizyme, Nanostring, Incyte, Roche, AstraZeneca; personal fees (consulting) from Servier. JS: Clinical study support from Merck to institution during the conduct of the study; grants outside the submitted work from Seattle Genetics, Bristol‐Myers Squibb, Pharmacyclics, AstraZeneca and Imbrium; personal fees outside the submitted work from Seattle Genetics, Bristol‐Myers Squibb, Pharmacyclics and AstraZeneca. AS: Institutional research grant from Merck during the conduct of the study; institutional research grant outside the submitted work from Merck, Roche, Pfizer, Bayer, Novartis, MEI‐Pharma and ADCT Therapeutics. AC: Employee at Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and stockholder for Merck & Co., Inc., Kenilworth, NJ, USA. RO: Employee of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and stockholder for Merck & Co., Inc., Kenilworth, NJ, USA. PM: Employee at and received travel accommodations/expenses from Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and stockholder for Merck & Co., Inc., Kenilworth, NJ, USA. BC: Research support to institution for clinical trial from Merck, Genetech, Celgene, Triphase, Acerta, Seattle Genetics, Millennium, Immunomedics, Cephalon.
References
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- Tsimberidou AM, O'Brien S, Khouri I, Giles FJ, Kantarjian HM, Champlin R, et al. Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem‐cell transplantation. J Clin Oncol. 2006;24:2343–51. - PubMed
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- Cwynarski K, van Biezen A, de Wreede L, Stilgenbauer S, Bunjes D, Metzner B, et al. Autologous and allogeneic stem‐cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2012;30:2211–7. - PubMed
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