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Clinical Trial
. 2020 Jul;190(2):e117-e120.
doi: 10.1111/bjh.16762. Epub 2020 Jun 16.

Pembrolizumab in relapsed or refractory Richter syndrome

Affiliations
Clinical Trial

Pembrolizumab in relapsed or refractory Richter syndrome

Philippe Armand et al. Br J Haematol. 2020 Jul.
No abstract available

Keywords: PD-1; Richter syndrome; chronic lymphocytic leukaemia; immunotherapy; pembrolizumab.

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Conflict of interest statement

PA: Consultancy, research funding (institution) and personal fees from Merck and Bristol‐Myers Squibb during the conduct of the study; consultancy outside the submitted work for Pfizer, Affimed, Adaptive, Infinity, ADC Therapeutics, Celgene, Morphosys, Daiichi Sankyo, Miltenyi, Tessa, C4, GenMab; research funding outside the submitted work from Affimed, Adaptive, Roche, Tensha, Otsuka, Sigma Tau, Genentech, IGM. NM: No conflicts to disclose. DM: Clinical study support from Merck during the conduct of the study; personal fees (lectures) from Roche, Takeda, Merck and Bristol‐Myers Squibb outside the submitted work. JZ: Consultancy role with Seattle Genetics, Mundi Pharma , Verastem and Kyowa Kirin; member of a speaker's bureau for Seattle Genetics and Spectrum. BE: Grants from Janssen, Roche, AbbVie, Gilead and BeiGene; personal fees from Janssen, Roche, Novartis, Gilead, Celgene, AstraZeneca, Oxford Biomedica (UK), Adaptive Biotechnologies and ArQule. ZG: No conflicts to disclose. EH: Research funding/grants from Merck, AstraZeneca, Bristol‐Myers Squibb, Celgene, Merck Serono; personal advisory board fees from AstraZeneca; advisory board payment to institution from Merck, Roche and Gilead. JMP: personal fees from Gilead, Pharmacyclics and AstraZeneca. TP: No conflicts to disclose. VR: Non‐financial research funding from ArgenX; personal fees (advisory board) from Gilead, Infinity, Merck, Bristol‐Myers Squibb, Epizyme, Nanostring, Incyte, Roche, AstraZeneca; personal fees (consulting) from Servier. JS: Clinical study support from Merck to institution during the conduct of the study; grants outside the submitted work from Seattle Genetics, Bristol‐Myers Squibb, Pharmacyclics, AstraZeneca and Imbrium; personal fees outside the submitted work from Seattle Genetics, Bristol‐Myers Squibb, Pharmacyclics and AstraZeneca. AS: Institutional research grant from Merck during the conduct of the study; institutional research grant outside the submitted work from Merck, Roche, Pfizer, Bayer, Novartis, MEI‐Pharma and ADCT Therapeutics. AC: Employee at Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and stockholder for Merck & Co., Inc., Kenilworth, NJ, USA. RO: Employee of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and stockholder for Merck & Co., Inc., Kenilworth, NJ, USA. PM: Employee at and received travel accommodations/expenses from Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and stockholder for Merck & Co., Inc., Kenilworth, NJ, USA. BC: Research support to institution for clinical trial from Merck, Genetech, Celgene, Triphase, Acerta, Seattle Genetics, Millennium, Immunomedics, Cephalon.

References

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    1. Parikh SA, Rabe KG, Call TG, Zent CS, Habermann TM, Ding W, et al. Diffuse large B‐cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): a cohort study of newly diagnosed patients. Br J Haematol. 2013;162:774–82. - PMC - PubMed
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