Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun 12;6(2):84.
doi: 10.3390/jof6020084.

Clinical Relevance and Characteristics of Aspergillus calidoustus and Other Aspergillus Species of Section Usti

Emmanouil Glampedakis  1 , Véronique Erard  2 , Frederic Lamoth  1   3
Affiliations
Review

Clinical Relevance and Characteristics of Aspergillus calidoustus and Other Aspergillus Species of Section Usti

Emmanouil Glampedakis et al. J Fungi (Basel). .

Abstract

The Aspergilli of section Usti (group ustus) are represented by over 20 species, of which Aspergillus calidoustus is the most relevant human pathogen. Invasive aspergillosis (IA) caused by these fungi is rare but could represent an emerging issue among the expanding population of patients with long-term immunosuppression receiving antifungal prophylaxis. Clinicians should be aware of this unusual type of IA, which often exhibits distinct clinical features, such as an insidious and prolonged course and a high occurrence of extra-pulmonary manifestations, such as skin/soft tissue or brain lesions. Moreover, these Aspergillus spp. pose a therapeutic challenge because of their decreased susceptibility to azole drugs. In this review, we outline the microbiological and clinical characteristics of IA due to Aspergillus spp. of section Usti and discuss the therapeutic options.

Keywords: Aspergillus granulosus; Aspergillus insuetus; Aspergillus keveii; Aspergillus pseudodeflectus; Aspergillus puniceus; Aspergillus ustus; invasive aspergillosis.

PubMed Disclaimer

Conflict of interest statement

F.L. took part in advisory boards for Gilead.

Figures

Figure 1
Figure 1
Morphological aspects of Aspergillus calidoustus. Macroscopic aspect of the colony on Sabouraud dextrose agar medium, top (left) and reverse (middle). Microscopic aspect (1000 ×) of a conidial head (staining: lactophenol blue) (right). Note: rough ornamentation of conidia is not visible here and could better visualized by scanning electron microscopy.
See this image and copyright information in PMC

References

    1. Kontoyiannis D.P., Marr K.A., Park B.J., Alexander B.D., Anaissie E.J., Walsh T.J., Ito J., Andes D.R., Baddley J.W., Brown J.M., et al. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin. Infect. Dis. 2010;50:1091–1100. doi: 10.1086/651263. - DOI - PubMed
    1. Pagano L., Caira M., Candoni A., Offidani M., Martino B., Specchia G., Pastore D., Stanzani M., Cattaneo C., Fanci R., et al. Invasive aspergillosis in patients with acute myeloid leukemia: A SEIFEM-2008 registry study. Haematologica. 2010;95:644–650. doi: 10.3324/haematol.2009.012054. - DOI - PMC - PubMed
    1. Pappas P.G., Alexander B.D., Andes D.R., Hadley S., Kauffman C.A., Freifeld A., Anaissie E.J., Brumble L.M., Herwaldt L., Ito J., et al. Invasive fungal infections among organ transplant recipients: Results of the Transplant-Associated Infection Surveillance Network (TRANSNET) Clin. Infect. Dis. 2010;50:1101–1111. doi: 10.1086/651262. - DOI - PubMed
    1. Steinbach W.J., Marr K.A., Anaissie E.J., Azie N., Quan S.P., Meier-Kriesche H.U., Apewokin S., Horn D.L. Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. J. Infect. 2012;65:453–464. doi: 10.1016/j.jinf.2012.08.003. - DOI - PubMed
    1. Lamoth F., Chung S.J., Damonti L., Alexander B.D. Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis. Clin. Infect. Dis. 2017;64:1619–1621. doi: 10.1093/cid/cix130. - DOI - PubMed

LinkOut - more resources