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Comment
. 2020 Sep;43(9):649-650.
doi: 10.1016/j.tins.2020.06.004. Epub 2020 Jun 13.

Local Sourcing of Secretory Proteins in Faraway Places

Ryan J Farrell  1 , Timothy A Ryan  2
Affiliations
Comment

Local Sourcing of Secretory Proteins in Faraway Places

Ryan J Farrell et al. Trends Neurosci. 2020 Sep.

Abstract

A recent paper by Carter et al. identifies a novel organelle, the ribosome-associated vesicle (RAV), that might serve as a portable, local factory for producing proteins destined for the secretory pathway. The appearance of RAVs in dendrites suggests they may serve to generate membrane and secreted proteins in distal processes.

Keywords: endoplasmic reticulum; local translation; mitochondria.

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Comment on

  • Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.
    Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Wills ZP, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z. Carter SD, et al. Sci Adv. 2020 Apr 1;6(14):eaay9572. doi: 10.1126/sciadv.aay9572. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32270040 Free PMC article.

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