Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May 29:11:1081.
doi: 10.3389/fimmu.2020.01081. eCollection 2020.

Innate Immune Sensing by Cells of the Adaptive Immune System

Tanja Stögerer  1 , Simona Stäger  1
Affiliations
Review

Innate Immune Sensing by Cells of the Adaptive Immune System

Tanja Stögerer et al. Front Immunol. .

Abstract

Sensing of microbes or of danger signals has mainly been attributed to myeloid innate immune cells. However, T and B cells also express functional pattern recognition receptors (PRRs). In these cells, PRRs mediate signaling cascades that result in different functions depending on the cell's activation and/or differentiation status, on the environment, and on the ligand/agonist. Some of these functions are beneficial for the host; however, some are detrimental and are exploited by pathogens to establish persistent infections. In this review, we summarize the available literature on innate immune sensing by cells of the adaptive immune system and discuss possible implications for chronic infections.

Keywords: B and T cells; DAMPs; PRRs; TLRs; adaptive immunity; chronic infections.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Summary of pathways involved in innate immune sensing in B cells.
Figure 2
Figure 2
Summary of pathways involved in innate immune sensing in T cells.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gururajan M, Jacob J, Pulendran B. Toll-Like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS ONE. (2007) 2:e863. 10.1371/journal.pone.0000863 - DOI - PMC - PubMed
    1. Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, et al. . Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. (2002) 168:4531–7. 10.4049/jimmunol.168.9.4531 - DOI - PubMed
    1. Dorner M, Brandt S, Tinguely M, Zucol F, Bourquin JP, Zauner L, et al. . Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production. Immunology. (2009) 128:573–9. 10.1111/j.1365-2567.2009.03143.x - DOI - PMC - PubMed
    1. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. (2009) 182:7459–72. 10.4049/jimmunol.0900270 - DOI - PMC - PubMed
    1. Hayashi EA, Akira S, Nobrega A. Role of TLR in B cell development: signaling through TLR4 promotes B cell maturation and is inhibited by TLR2. J Immunol. (2005) 174:6639–47. 10.4049/jimmunol.174.11.6639 - DOI - PubMed

Publication types

Substances

Grants and funding

LinkOut - more resources