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Review
. 2020 May 29:11:1081.
doi: 10.3389/fimmu.2020.01081. eCollection 2020.

Innate Immune Sensing by Cells of the Adaptive Immune System

Tanja Stögerer  1 , Simona Stäger  1
Affiliations
Review

Innate Immune Sensing by Cells of the Adaptive Immune System

Tanja Stögerer et al. Front Immunol. .

Abstract

Sensing of microbes or of danger signals has mainly been attributed to myeloid innate immune cells. However, T and B cells also express functional pattern recognition receptors (PRRs). In these cells, PRRs mediate signaling cascades that result in different functions depending on the cell's activation and/or differentiation status, on the environment, and on the ligand/agonist. Some of these functions are beneficial for the host; however, some are detrimental and are exploited by pathogens to establish persistent infections. In this review, we summarize the available literature on innate immune sensing by cells of the adaptive immune system and discuss possible implications for chronic infections.

Keywords: B and T cells; DAMPs; PRRs; TLRs; adaptive immunity; chronic infections.

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Figures

Figure 1
Figure 1
Summary of pathways involved in innate immune sensing in B cells.
Figure 2
Figure 2
Summary of pathways involved in innate immune sensing in T cells.
See this image and copyright information in PMC

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