Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 8;11(6):1067-1068.
doi: 10.1021/acsmedchemlett.0c00190. eCollection 2020 Jun 11.

A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin

Tiziano Marzo  1 , Luigi Messori  2
Affiliations

A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin

Tiziano Marzo et al. ACS Med Chem Lett. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Chemical structure of auranofin.
See this image and copyright information in PMC

References

    1. Gordon D. E.; Jang G. M.; Bouhaddou M.; Xu J.; Obernier K.; White K. M.; O’Meara M. J.; Rezelj V. V.; Guo J. Z.; Swaney D. L.; Tummino T. A.; Huettenhain R.; Kaake R. M.; Richards A. L.; Tutuncuoglu B.; Foussard H.; Batra J.; Haas K.; Modak M.; Kim M.; Haas P.; Polacco B. J.; Braberg H.; Fabius J. M.; Eckhardt M.; Soucheray M.; Bennett M. J.; Cakir M.; McGregor M. J.; Li Q.; Meyer B.; Roesch F.; Vallet T.; Mac Kain A.; Miorin L.; Moreno E.; Chi Naing Z. Z.; Zhou Y.; Peng S.; Shi Y.; Zhang Z.; Shen W.; Kirby I. T.; Melnyk J. E.; Chorba J. S.; Lou K.; Dai S. A.; Barrio-Hernandez I.; Memon D.; Hernandez-Armenta C.; Lyu J.; Mathy C. J. P.; Perica T.; Pilla K. B.; Ganesan S. J.; Saltzberg D. J.; Rakesh R.; Liu X.; Rosenthal S. B.; Calviello L.; Venkataramanan S.; Liboy-Lugo J.; Lin Y.; Huang X.-P.; Liu Y. F.; Wankowicz S. A.; Bohn M.; Safari M.; Ugur F. S.; Koh C.; Savar N. S.; Tran Q. D.; Shengjuler D.; Fletcher S. J.; O’Neal M. C.; Cai Y.; Chang J. C. J.; Broadhurst D. J.; Klippsten S.; Sharp P. P.; Wenzell N. A.; Kuzuoglu D.; Wang H.-Y.; Trenker R.; Young J. M.; Cavero D. A.; Hiatt J.; Roth T. L.; Rathore U.; Subramanian A.; Noack J.; Hubert M.; Stroud R. M.; Frankel A. D.; Rosenberg O. S.; Verba K. A.; Agard D. A.; Ott M.; Emerman M.; Jura N.; von Zastrow M.; Verdin E.; Ashworth A.; Schwartz O.; d’Enfert C.; Mukherjee S.; Jacobson M.; Malik H. S.; Fujimori D. G.; Ideker T.; Craik C. S.; Floor S. N.; Fraser J. S.; Gross J. D.; Sali A.; Roth B. L.; Ruggero D.; Taunton J.; Kortemme T.; Beltrao P.; Vignuzzi M.; García-Sastre A.; Shokat K. M.; Shoichet B. K.; Krogan N. J. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 2020, 10.1038/s41586-020-2286-9. - DOI - PMC - PubMed
    1. Roder C.; Thomson M. J. Auranofin: Repurposing an Old Drug for a Golden New Age. Drugs R&D 2015, 15, 13–20. 10.1007/s40268-015-0083-y. - DOI - PMC - PubMed
    1. Zhang X.; Selvaraju K.; Saei A. A.; D’Arcy P.; Zubarev R. A.; Arnér E. S.; Linder S. Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug. Biochimie 2019, 162, 46–54. 10.1016/j.biochi.2019.03.015. - DOI - PubMed
    1. Liu N.; Li X.; Huang H.; Zhao C.; Liao S.; Yang C.; Liu S.; Song W.; Lu X.; Lan X.; Chen X.; Yi S.; Xu L.; Jiang L.; Zhao C.; Dong X.; Zhou P.; Li S.; Wang S.; Shi X.; Dou P. Q.; Wang X.; Liu J. Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth. Oncotarget 2014, 5, 5453–5471. 10.18632/oncotarget.2113. - DOI - PMC - PubMed
    1. Savarino A.; Shytaj I. L. Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS. Retrovirology 2015, 12, 51.10.1186/s12977-015-0178-0. - DOI - PMC - PubMed