Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Jun 15;21(12):4250.
doi: 10.3390/ijms21124250.

Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders"

Yuzuru Imai  1
Affiliations
Editorial

Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders"

Yuzuru Imai. Int J Mol Sci. .

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by age-dependent motor dysfunction and degeneration of the midbrain dopaminergic neurons [...].

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Summary of papers in this Special Issue. Articles in red and in black indicate original and review articles, respectively. 6-OHDA = 6-hydroxydopamine, MPTP = 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, PD = Parkinson’s disease.
See this image and copyright information in PMC

References

    1. Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis. Science. 1983;219:979–980. doi: 10.1126/science.6823561. - DOI - PubMed
    1. Mizuno Y., Saitoh T., Sone N. Inhibition of Mitochondrial NADH-Ubiquinone Oxidoreductase Activity by 1-methyl-4-phenylpyridinium Ion. Biochem. Biophys. Res. Commun. 1987;143:294–299. doi: 10.1016/0006-291X(87)90664-4. - DOI - PubMed
    1. Kitayama S., Mitsuhata C., Davis S., Wang J.B., Sato T., Morita K., Uhl G.R., Dohi T. MPP+ Toxicity and Plasma Membrane Dopamine Transporter: Study Using Cell Lines Expressing the Wild-Type and Mutant Rat Dopamine Transporters. Biochim. Biophys. Acta. 1998;1404:305–313. doi: 10.1016/S0167-4889(98)00071-8. - DOI - PubMed
    1. Kinoshita K., Tada Y., Muroi Y., Unno T., Ishii T. Selective Loss of Dopaminergic Neurons in the Substantia Nigra Pars Compacta after Systemic Administration of MPTP Facilitates Extinction Learning. Life Sci. 2015;137:28–36. doi: 10.1016/j.lfs.2015.07.017. - DOI - PubMed
    1. Ishii T., Kinoshita K.I., Muroi Y. Serotonin 5-HT4 receptor Agonists Improve Facilitation of Contextual Fear Extinction in an MPTP-Induced Mouse Model of Parkinson’s Disease. Int. J. Mol. Sci. 2019;20:5340. doi: 10.3390/ijms20215340. - DOI - PMC - PubMed

Publication types

MeSH terms