Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May 15;19(1):645-660.
doi: 10.1007/s40200-020-00536-x. eCollection 2020 Jun.

The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials

Mehrnaz Morvaridi  1 , Elham Rayyani  2 , Malihe Jaafari  2 , Alireza Khiabani  3 , Mehran Rahimlou  4
Affiliations
Review

The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials

Mehrnaz Morvaridi et al. J Diabetes Metab Disord. .

Abstract

Purpose: Considering the present controversies on the association between green coffee supplementation and cardio metabolic risk factors, this systematic review and meta-analysis was conducted to evaluate the effect of green coffee supplementation on cardio metabolic risk factors.

Method: A systematic literature search was performed throughout the PubMed, Embase, Scopus, and Web of Science databases up to October 2019. As a result, all randomized controlled trials over the effect of green coffee supplementation on fasting blood sugar (FBS), insulin, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C - reactive protein (CRP), and homeostatic model assessment for insulin resistance (HOMA-IR) in adults were examined. Data were extracted from the relevant studies and analyzed using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI).

Results: After excluding the irrelevant articles, 27 studies were included in the final analysis. Pooled results revealed that green coffee supplementation significantly reduced FBS (WMD = -2.28, 95% CI: -4.49 to -0.07, P = 0.043), insulin (WMD = -0.53, 95% CI: -0.93 to -0.14, P = 0.008), and triglyceride (WMD = -9.28, 95% CI: -14.93 to - 3.63, P = 0.001). Furthermore, green coffee supplementation increased the HDL levels (WMD = 1.33, 95% CI: 0.08 to 2.58, P = 0.037). However, the changes in HOMA-IR, LDL, and CRP levels were not significant (P > 0.05).

Conclusion: This meta-analysis indicated that green coffee supplementation significantly decreased FBS, insulin, and triglyceride, but improved HDL. No statistically significant improvement was found in HOMA-IR, LDL, and CRP indices following the green coffee supplementation.

Keywords: Cardiometabolic risk factors; Chlorogenic acid; Fasting blood sugar; Green-coffee; Meta-analysis.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestNo conflict of interest was declared.

Figures

Fig. 1
Fig. 1
Flow diagram of literature search according to the PRISMA statement
Fig. 2
Fig. 2
Forest plot summarizing the association between green coffee extract supplementation on circulating FBS concentrations
Fig. 3
Fig. 3
Funnel plots detailing publication bias in the selected studies of the relation between intakes of green coffee extract and FBS
Fig. 4
Fig. 4
Forest plot summarizing the association between green coffee extract supplementation on circulating insulin concentrations
Fig. 5
Fig. 5
Forest plot summarizing the association between green coffee extract supplementation on HOMA-IR
Fig. 6
Fig. 6
Forest plot summarizing the association between green coffee extract supplementation on TG
Fig. 7
Fig. 7
Forest plot summarizing the association between green coffee extract supplementation on Total cholesterol
Fig. 8
Fig. 8
Forest plot summarizing the association between green coffee extract supplementation on LDL
Fig. 9
Fig. 9
Forest plot summarizing the association between green coffee extract supplementation on HDL
Fig. 10
Fig. 10
Forest plot summarizing the association between green coffee extract supplementation on CRP
See this image and copyright information in PMC

References

    1. Zhang D, Tang X, Shen P, Si Y, Liu X, Xu Z, Wu J, Zhang J, Lu P, Lin H, Gao P. Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study. BMJ Open. 2019;9(3):e024476. - PMC - PubMed
    1. Takami H, Nakamoto M, Uemura H, Katsuura S, Yamaguchi M, Hiyoshi M, Sawachika F, Juta T, Arisawa K. Inverse correlation between coffee consumption and prevalence of metabolic syndrome: baseline survey of the Japan multi-institutional collaborative cohort (J-MICC) study in Tokushima. Japan J Epidemiol. 2013;23(1):12–20. - PMC - PubMed
    1. Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, D’Agostino RB, Gaziano JM, Vasan RS. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. 2007;116(5):480–488. - PubMed
    1. Heidemann C, Scheidt-Nave C, Richter A, Mensink GB. Dietary patterns are associated with cardiometabolic risk factors in a representative study population of German adults. Br J Nutr. 2011;106(8):1253–1262. - PubMed
    1. Goodpaster BH, DeLany JP, Otto AD, Kuller L, Vockley J, South-Paul JE, et al. Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial. JAMA. 2010;304(16):1795–1802. - PMC - PubMed