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. 2018 Nov 26:2018:10.17912/micropub.biology.000074.
doi: 10.17912/micropub.biology.000074.

2018 Update on Protein-Protein Interaction Data in WormBase

Jaehyoung Cho  1 , Christian Grove  1 , Kimberly Van Auken  1 , Juancarlos Chan  1 , Sibyl Gao  2 , Paul Sternberg  1
Affiliations

2018 Update on Protein-Protein Interaction Data in WormBase

Jaehyoung Cho et al. MicroPubl Biol. .
No abstract available

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Figures

Figure 1
Figure 1
(A) Network diagram showing a map of C. elegans protein-protein interactions. This cluster includes 17,990 unique protein-protein interactions from 6,079 protein coding genes in the C. elegans genome. This map was generated by Cytoscape 3.6.1. (B) Comparisons of the curation status between the major databases for C. elegans protein-protein interaction data. As of September 2018, IMEx has 16,443 total and 12,433 unique protein-protein interactions with 4,967 unique genes annotated from 253 papers. BioGRID has 6,274 total and 5,734 unique protein-protein interactions with 3,212 unique genes annotated from 174 papers. In contrast, WormBase has 28,279 total and 17,990 unique protein-protein interactions with 6,079 unique genes annotated from 1,251 papers. The inserted bar-graph shows the number of unique genes curated for the protein-protein interactions in each database. (C) Statistics of the experimental evidence types curated for the protein interaction data set in WormBase. The experimental evidence type for each protein interaction is annotated as described in the BioGRID curation guide for ‘physical experimental systems’ (https://wiki.thebiogrid.org/doku.php/curation_guide:biochemical_experimental_systems). However, in WormBase, ‘Colocalization’ is annotated as an evidence type only when the interaction is supported by other detection methods. Within the total 18,734 yeast two-hybrid interactions, 17,312 interactions come from large-scale, high-throughput studies and 1,422 come from small-scale studies.
See this image and copyright information in PMC

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