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Review
. 2020 Jun 5:3:84.
doi: 10.1038/s41746-020-0290-y. eCollection 2020.

The Project Baseline Health Study: a step towards a broader mission to map human health

Kristine Arges  1 , Themistocles Assimes  2 , Vikram Bajaj  2 , Suresh Balu  1 , Mustafa R Bashir  1 , Laura Beskow  3 , Rosalia Blanco  1 , Robert Califf  4 , Paul Campbell  1 , Larry Carin  1 , Victoria Christian  1 , Scott Cousins  1 , Millie Das  2 , Marie Dockery  1 , Pamela S Douglas  1 , Ashley Dunham  1 , Julie Eckstrand  1 , Dominik Fleischmann  2 , Emily Ford  1 , Elizabeth Fraulo  1 , John French  1 , Sanjiv S Gambhir  2 , Geoffrey S Ginsburg  1 , Robert C Green  5 , Francois Haddad  2 , Adrian Hernandez  1 , John Hernandez  6 , Erich S Huang  1 , Glenn Jaffe  1 , Daniel King  1 , Lynne H Koweek  1 , Curtis Langlotz  2 , Yaping J Liao  2 , Kenneth W Mahaffey  2 , Kelly Marcom  1 , William J Marks Jr  2   4 , David Maron  2 , Reid McCabe  1 , Shannon McCall  1 , Rebecca McCue  2 , Jessica Mega  4 , David Miller  4 , Lawrence H Muhlbaier  1 , Rajan Munshi  2 , L Kristin Newby  1 , Ezra Pak-Harvey  1 , Bray Patrick-Lake  1 , Michael Pencina  1 , Eric D Peterson  1 , Fatima Rodriguez  2 , Scarlet Shore  4 , Svati Shah  1 , Steven Shipes  1 , George Sledge  2 , Susie Spielman  2 , Ryan Spitler  2 , Terry Schaack  7 , Geeta Swamy  1 , Martin J Willemink  2 , Charlene A Wong  1
Affiliations
Review

The Project Baseline Health Study: a step towards a broader mission to map human health

Kristine Arges et al. NPJ Digit Med. .

Abstract

The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical information system that accounts for the highly complex interplay of biological, behavioral, environmental, and social systems. The PBHS is a prospective, multicenter, longitudinal cohort study that aims to enroll thousands of participants with diverse backgrounds who are representative of the entire health spectrum. Enrolled participants will be evaluated serially using clinical, molecular, imaging, sensor, self-reported, behavioral, psychological, environmental, and other health-related measurements. An initial deeply phenotyped cohort will inform the development of a large, expanded virtual cohort. The PBHS will contribute to precision health and medicine by integrating state of the art testing, longitudinal monitoring and participant engagement, and by contributing to the development of an improved platform for data sharing and analysis.

Keywords: Biomarkers; Cancer; Cardiovascular diseases; Data integration; Diagnosis.

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Conflict of interest statement

Competing interestsK.A. received research funding from Verily Inc. for work at Duke Clinical and Translational Science Institute. R.C. and J.H. are employed or have a leadership role at at Google Health. R.C. is also a Board member, Cytokinetics. M.D. receives research funding from Celgene, Abbvie, United Therapeutics, Varian, Genzyme, Novartis, Verily Inc., and consults or receives honoraria from Astra Zeneca, Bristol Myer Squibb. A.H. receives research funding from American Regent, AstraZeneca, Merck, Novartis, Verily Inc., and consults for Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Merck, Novartis, and Sanofi. C.L. has the following engagements Shareholder and Advisory Board, whiterabbit.ai; Shareholder, Nines.ai; Advisory Board, Nines.ai; Shareholder, GalileoCDS, Inc.; Advisory Board, GalileoCDS, Inc; Shareholder and Board of Directors Bunker Hill, Inc.; Research Grant, GE Healthcare; Departmental Research Grant, Koninklijke Philips NV; Departmental Research Grant, Siemens AG; School of Medicine Research Grant, Google, Inc.; Travel Grant, Canon Medical Systems Corp; Travel Grant, Siemens Healthineers. S.S.G. is a consultant or receives funding from several companies that work in the healthcare space although none of these companies are directly involved in the current work. K.W.M.’s financial disclosure can be viewed at http://med.stanford.edu/profiles/kenneth-mahaffey. W.J.M., J.M., D.M., and S.S. are employed, have a leadership role, or receive equity from Verily Inc. J.M. is also a Board Member, Danaher. L.K.N. received research grant support from Verily Inc.

Figures

Fig. 1
Fig. 1. Overview of participant flow.
Participants are recruited and screened. After the initial screening period, participants have annual follow-up visits in person. A broad range of health measurements are conducted in clinic, at home, and remotely. Participants are able to provide input and have access to communication with study staff on a more continuous basis between study visits. The current duration of the follow up is to occur over the course of the next four years. *Study watch image used with permission from Verily Inc.
Fig. 2
Fig. 2. Results display.
Results of physical performance testing are returned through the Project Baseline Mobile app. Results of each test are enhanced with contextual information including a description of the study procedure, normative data, and links to additional resources from both the lay and scientific communities.
See this image and copyright information in PMC

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